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Bioinformatics identification of cod...

Park, Jane.

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Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers./
Author:	Park, Jane.
Description:	143 p.
Notes:	Adviser: Mark Redston.
Contained By:	Masters Abstracts International40-03.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ63104
ISBN:	0612631044

Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.
Park, Jane.

Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers. - 143 p.

Adviser: Mark Redston.

Thesis (M.Sc.)--University of Toronto (Canada), 2001.

High frequency microsatellite instability (MSI-H) colorectal carcinomas (CRCs) display MMR deficiency and account for about 15% of human colorectal cancers. Gene inactivation via mononucleotide tract frameshift mutations is characteristic of the pathogenesis of MSI-H colorectal carcinomas. Frameshift mutations have only been described in selected candidate genes including <italic> TGFβRII, IGFIIR, BAX</italic> and others. We developed “Kangaroo”, a program capable of highly specialized searches in nucleotide and protein sequence databases. Utilizing Kangaroo, we identified genes with coding polyadenine tracts that had functional significance in cell cycle regulation. Our results revealed widespread novel mutations in mismatch repair deficient colorectal cancers, while Kangaroo provided a method for genome scanning to identify candidate mutation hot spots in evolution and human disease.

ISBN: 0612631044Subjects--Topical Terms:

1017730
Biology, Genetics.

Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.
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005 20110425
008 110425s2001 eng d
020 $a 0612631044
035 $a (UnM)AAIMQ63104
035 $a AAIMQ63104
040 $a UnM $c UnM
100 1 $a Park, Jane. $3 1251042
245 1 0 $a Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.
300 $a 143 p.
500 $a Adviser: Mark Redston.
500 $a Source: Masters Abstracts International, Volume: 40-03, page: 0647.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2001.
520 $a High frequency microsatellite instability (MSI-H) colorectal carcinomas (CRCs) display MMR deficiency and account for about 15% of human colorectal cancers. Gene inactivation via mononucleotide tract frameshift mutations is characteristic of the pathogenesis of MSI-H colorectal carcinomas. Frameshift mutations have only been described in selected candidate genes including <italic> TGFβRII, IGFIIR, BAX</italic> and others. We developed “Kangaroo”, a program capable of highly specialized searches in nucleotide and protein sequence databases. Utilizing Kangaroo, we identified genes with coding polyadenine tracts that had functional significance in cell cycle regulation. Our results revealed widespread novel mutations in mismatch repair deficient colorectal cancers, while Kangaroo provided a method for genome scanning to identify candidate mutation hot spots in evolution and human disease.
590 $a School code: 0779.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0307
690 $a 0369
690 $a 0992
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 40-03.
790 $a 0779
790 1 0 $a Redston, Mark, $e advisor
791 $a M.Sc.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ63104