東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The investigation of factors affecti...

Hodges, Craig Alan.

FindBook

Google Book

Amazon

博客來

The investigation of factors affecting chromosome segregation during female meiosis.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The investigation of factors affecting chromosome segregation during female meiosis./
作者:	Hodges, Craig Alan.
面頁冊數:	127 p.
附註:	Adviser: Patricia A. Hunt.
Contained By:	Dissertation Abstracts International63-08B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3061311
ISBN:	0493770038

The investigation of factors affecting chromosome segregation during female meiosis.
Hodges, Craig Alan.

The investigation of factors affecting chromosome segregation during female meiosis. - 127 p.

Adviser: Patricia A. Hunt.

Thesis (Ph.D.)--Case Western Reserve University (Health Sciences), 2002.

An estimated 10–25% of all human conceptuses are aneuploid, resulting in devastating clinical consequences. Although little is known about the origin of aneuploidy, most errors have been attributed to the maternal first meiotic division (MI). The first meiotic division is a specialized cell division that requires the modified action of two chromosome-associated protein complexes, the kinetochore and sister chromatid cohesion. The objective of this thesis was to investigate factors that affect sister kinetochore function and sister chromatid cohesion during MI to gain a better understanding of female meiosis and nondisjunction.

ISBN: 0493770038Subjects--Topical Terms:

1017730
Biology, Genetics.

The investigation of factors affecting chromosome segregation during female meiosis.
LDR:03404nam 2200301 a 45 001 927232
005 20110425
008 110425s2002 eng d
020 $a 0493770038
035 $a (UnM)AAI3061311
035 $a AAI3061311
040 $a UnM $c UnM
100 1 $a Hodges, Craig Alan. $3 1250783
245 1 0 $a The investigation of factors affecting chromosome segregation during female meiosis.
300 $a 127 p.
500 $a Adviser: Patricia A. Hunt.
500 $a Source: Dissertation Abstracts International, Volume: 63-08, Section: B, page: 3564.
502 $a Thesis (Ph.D.)--Case Western Reserve University (Health Sciences), 2002.
520 $a An estimated 10–25% of all human conceptuses are aneuploid, resulting in devastating clinical consequences. Although little is known about the origin of aneuploidy, most errors have been attributed to the maternal first meiotic division (MI). The first meiotic division is a specialized cell division that requires the modified action of two chromosome-associated protein complexes, the kinetochore and sister chromatid cohesion. The objective of this thesis was to investigate factors that affect sister kinetochore function and sister chromatid cohesion during MI to gain a better understanding of female meiosis and nondisjunction.
520 $a Precocious sister chromatid segregation (PSCS) at MI has been postulated to be a major contributor to human nondisjunction. To investigate factors affecting PSCS, we used the XO mouse as a model since the sister chromatids of the single X chromosome frequently segregate at MI and the propensity for PSCS is influenced by genetic background. Our analysis demonstrated that differences in PSCS between strains was due to the action of an autosomal trans-acting factor or factors. Our studies also showed that this factor does not involve synapsis since we were unable to correlate synapsis with PSCS. Finally, we demonstrated that, contrary to expectation, sister kinetochore morphology does not predict sister kinetochore function.
520 $a During our investigation of factors affecting chromosome segregation in the female, we observed a sexual dimorphism in centromere-associated proteins. Two protein components of the synaptonemal complex, SCP2 and SCP3, and the meiosis-specific cohesin, SMC1β, had all previously been reported to persist at the centromere until anaphase II during meiosis in the male. However, in the female we found that these proteins gradually disappear during dictyate arrest and are undetectable at subsequent meiotic divisions. Given the postulated role of these centromere-associated proteins in chromosome segregation, we hypothesize that this sexual dimorphism could provide an explanation for the difference in error frequency between male and female meiosis.
520 $a Lastly, in the course of these studies, a new technique that provides simultaneous cytological analysis of chromosome-associated proteins and chromosome number in oocytes and early embryos was developed. This technique provides a new means of understanding the relationship between chromosome-associated proteins and nondisjunction.
590 $a School code: 0499.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a Case Western Reserve University (Health Sciences). $3 1250782
773 0 $t Dissertation Abstracts International $g 63-08B.
790 $a 0499
790 1 0 $a Hunt, Patricia A., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3061311