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Genetics and fine mapping of alcohol...

Peirce, Jeremy Leonard.

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Genetics and fine mapping of alcohol preference in C57Bl/6 mice.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Genetics and fine mapping of alcohol preference in C57Bl/6 mice./
Author:	Peirce, Jeremy Leonard.
Description:	180 p.
Notes:	Adviser: Lee M. Silver.
Contained By:	Dissertation Abstracts International63-01B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3039705
ISBN:	049352925X

Genetics and fine mapping of alcohol preference in C57Bl/6 mice.
Peirce, Jeremy Leonard.

Genetics and fine mapping of alcohol preference in C57Bl/6 mice. - 180 p.

Adviser: Lee M. Silver.

Thesis (Ph.D.)--Princeton University, 2002.

This dissertation describes the discovery of two new alcohol preference loci in C57Bl/6 mice, and details several attempts at fine mapping alcohol preference loci generally. Fine mapping was attempted using three populations designed for the purpose—AIL, AIL backcross, and RIST—was performed, and the results described. These techniques allowed significant fine mapping of Alcp1 with a 6.7-fold increase in resolution over previous maps. Suggestive fine mapping of Alcp3 was also achieved.

ISBN: 049352925XSubjects--Topical Terms:

1017730
Biology, Genetics.

Genetics and fine mapping of alcohol preference in C57Bl/6 mice.
LDR:01811nam 2200277 a 45 001 927225
005 20110425
008 110425s2002 eng d
020 $a 049352925X
035 $a (UnM)AAI3039705
035 $a AAI3039705
040 $a UnM $c UnM
100 1 $a Peirce, Jeremy Leonard. $3 1250775
245 1 0 $a Genetics and fine mapping of alcohol preference in C57Bl/6 mice.
300 $a 180 p.
500 $a Adviser: Lee M. Silver.
500 $a Source: Dissertation Abstracts International, Volume: 63-01, Section: B, page: 0062.
502 $a Thesis (Ph.D.)--Princeton University, 2002.
520 $a This dissertation describes the discovery of two new alcohol preference loci in C57Bl/6 mice, and details several attempts at fine mapping alcohol preference loci generally. Fine mapping was attempted using three populations designed for the purpose—AIL, AIL backcross, and RIST—was performed, and the results described. These techniques allowed significant fine mapping of Alcp1 with a 6.7-fold increase in resolution over previous maps. Suggestive fine mapping of Alcp3 was also achieved.
520 $a Despite these advances, it is imperative that new techniques and mapping populations be developed if QTL fine mapping is to succeed on a regular basis. To this end, AIL-based recombinant inbred (ARI) lines were created. ARI lines have a unique recombination density approximately 150% of that found in the current BXD RI set. Several alternate approaches to fine mapping including a novel RI x congenic cross designed to map recessive loci are proposed.
590 $a School code: 0181.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 63-01B.
790 $a 0181
790 1 0 $a Silver, Lee M., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3039705