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The role of two signaling pathways i...

Faber, Sonya C. Williams.

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The role of two signaling pathways in lens development.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of two signaling pathways in lens development./
Author:	Faber, Sonya C. Williams.
Description:	200 p.
Notes:	Adviser: Richard Lang.
Contained By:	Dissertation Abstracts International62-12B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3035292
ISBN:	0493481001

The role of two signaling pathways in lens development.
Faber, Sonya C. Williams.

The role of two signaling pathways in lens development. - 200 p.

Adviser: Richard Lang.

Thesis (Ph.D.)--New York University, 2002.

Combined, these analyses indicate that Fgf and Bmp signaling have important roles in lens development and allow the construction of a schematic outlining how signaling pathways regulate downstream factors necessary for lens development.

ISBN: 0493481001Subjects--Topical Terms:

1017730
Biology, Genetics.

The role of two signaling pathways in lens development.
LDR:03209nam 2200289 a 45 001 927211
005 20110425
008 110425s2002 eng d
020 $a 0493481001
035 $a (UnM)AAI3035292
035 $a AAI3035292
040 $a UnM $c UnM
100 1 $a Faber, Sonya C. Williams. $3 1250761
245 1 0 $a The role of two signaling pathways in lens development.
300 $a 200 p.
500 $a Adviser: Richard Lang.
500 $a Source: Dissertation Abstracts International, Volume: 62-12, Section: B, page: 5506.
502 $a Thesis (Ph.D.)--New York University, 2002.
520 $a Combined, these analyses indicate that Fgf and Bmp signaling have important roles in lens development and allow the construction of a schematic outlining how signaling pathways regulate downstream factors necessary for lens development.
520 $a This Thesis seeks to clarify the understanding of signaling pathways that are necessary for the development and polarization of the mammalian lens. Ultimately the characterization how these pathways are involved in lens development may lead to the ability to recapitulate lens development in an <italic>in-vitro </italic> system and perhaps eventually to lens replacement therapies.
520 $a The body of this work is divided into three parts, the first identifies genetic tools, isolated for the purpose of probing the extent to which known signaling pathways participate in the various stages of lens development. This first section identifies a region of the <italic>Pax6</italic> gene that is conserved between mouse and man and is necessary and sufficient for directing expression to the developing lens and cornea. The second and third sections of this Thesis use this Pax6 enhancer to explore the temporal and spatial functions of two signaling molecules known previously to be involved in lens development. The second section seeks to find out to what extent Bone Morphogenetic Protein, (Bmp) signaling is required for lens polarization. Expression of a dominant negative form of a Bmp receptor using both the <italic>Pax6</italic> ectoderm enhancer and the α<italic>A</italic> crystallin promoter result in detrimental effects on development of the primary lens fiber cells, demonstrating a role for Bmp signaling in proper lens polarization. In the third and final section of this Thesis, Fibroblast Growth Factor (Fgf) signaling is shown in three separate experiments to have a role in early lens development, in that, both at the morphological and molecular levels, lens induction does not proceed normally if Fgfr activity is inhibited. First, explant experiments show reduced levels of Pax6 when presumptive lens ectoderm is cultured in the presence of Fgfr kinases inhibitors. Second, the expression of a dominant-negative Fgf receptor in the developing lens causes abnormalities. Finally, a genetic interaction between the lens inducer Bmp7, and Fgfr signaling is shown at the stage of lens induction.
590 $a School code: 0146.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a New York University. $3 515735
773 0 $t Dissertation Abstracts International $g 62-12B.
790 $a 0146
790 1 0 $a Lang, Richard, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3035292