東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The brain tumor gene product acts po...

Gee, Christopher C.

FindBook

Google Book

Amazon

博客來

The brain tumor gene product acts positively on decapentaplegic signaling.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The brain tumor gene product acts positively on decapentaplegic signaling./
作者:	Gee, Christopher C.
面頁冊數:	127 p.
附註:	Adviser: Allen Shearn.
Contained By:	Dissertation Abstracts International62-10B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3028272
ISBN:	049340323X

The brain tumor gene product acts positively on decapentaplegic signaling.
Gee, Christopher C.

The brain tumor gene product acts positively on decapentaplegic signaling. - 127 p.

Adviser: Allen Shearn.

Thesis (Ph.D.)--The Johns Hopkins University, 2002.

Mutations in the tumor suppressor gene <italic>brain tumor</italic> (<italic> brat</italic>) act recessively, yield overgrowth of <italic>Drosophila melanogaster </italic> larval brain lobes, and cause late third instar to early pupal lethality (Hankins GR 1991). Though not reported in earlier studies, <italic>brat</italic> heterozygotes exhibit wing vein defects at low frequencies. To gain a greater understanding of the role that the <italic>brat</italic> gene plays in fly development, I undertook a second chromosome deficiency screen using the deficiency kit provided by the Bloomington Stock Center. I scored wing vein defects in adult flies bearing one <italic>brat</italic> mutation and a second chromosome deficiency for evidence of intergenic noncomplementation. Three regions of the second chromosome exhibited intergenic noncomplementation with <italic> brat</italic> causing vein thickening or ectopic vein formation. Surprisingly, intergenic noncomplementation affected females and males differently. Closer examination of one of these regions identified <italic>thickveins</italic> (<italic>tkv</italic>) as a source of intergenic noncomplementation with <italic> brat</italic>. Because <italic>tkv </italic> is a Type I Transforming Growth Factor-β (TGF-β) receptor, these results link <italic>brat</italic> to signal transduction.

ISBN: 049340323XSubjects--Topical Terms:

1017730
Biology, Genetics.

The brain tumor gene product acts positively on decapentaplegic signaling.
LDR:03118nam 2200277 a 45 001 927201
005 20110425
008 110425s2002 eng d
020 $a 049340323X
035 $a (UnM)AAI3028272
035 $a AAI3028272
040 $a UnM $c UnM
100 1 $a Gee, Christopher C. $3 1250752
245 1 0 $a The brain tumor gene product acts positively on decapentaplegic signaling.
300 $a 127 p.
500 $a Adviser: Allen Shearn.
500 $a Source: Dissertation Abstracts International, Volume: 62-10, Section: B, page: 4346.
502 $a Thesis (Ph.D.)--The Johns Hopkins University, 2002.
520 $a Mutations in the tumor suppressor gene <italic>brain tumor</italic> (<italic> brat</italic>) act recessively, yield overgrowth of <italic>Drosophila melanogaster </italic> larval brain lobes, and cause late third instar to early pupal lethality (Hankins GR 1991). Though not reported in earlier studies, <italic>brat</italic> heterozygotes exhibit wing vein defects at low frequencies. To gain a greater understanding of the role that the <italic>brat</italic> gene plays in fly development, I undertook a second chromosome deficiency screen using the deficiency kit provided by the Bloomington Stock Center. I scored wing vein defects in adult flies bearing one <italic>brat</italic> mutation and a second chromosome deficiency for evidence of intergenic noncomplementation. Three regions of the second chromosome exhibited intergenic noncomplementation with <italic> brat</italic> causing vein thickening or ectopic vein formation. Surprisingly, intergenic noncomplementation affected females and males differently. Closer examination of one of these regions identified <italic>thickveins</italic> (<italic>tkv</italic>) as a source of intergenic noncomplementation with <italic> brat</italic>. Because <italic>tkv </italic> is a Type I Transforming Growth Factor-β (TGF-β) receptor, these results link <italic>brat</italic> to signal transduction.
520 $a <italic>decapentaplegic</italic> (<italic>dpp</italic>), a gene important to <italic>D. melanogaster</italic> development and a member of the TGF-β superfamily, regulates transcription of several genes in the wing imaginal disc. Reduced accumulation of proteins encoded by these genes in <italic> brat</italic> mutant larval tissues connects <italic>brat</italic> more specifically to <italic>dpp</italic> signaling. Because providing only a single copy of functional <italic>brat</italic> failed to suppress a phenotype caused by ectopic expression of a constitutively active TKV, <italic>brat</italic> appears to act upstream of the receptor in the <italic>dpp</italic> signaling pathway. I argue that these results implicate <italic>brat</italic> in TKV-DPP interactions. In this way, <italic>brain tumor</italic> acts as a positive regulator of <italic> dpp</italic> signaling.
590 $a School code: 0098.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 0 $a The Johns Hopkins University. $3 1017431
773 0 $t Dissertation Abstracts International $g 62-10B.
790 $a 0098
790 1 0 $a Shearn, Allen, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3028272