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A pharmacology primer = theory, applications, and methods /

Record Type:	Language materials, printed : Monograph/item
Title/Author:	A pharmacology primer/ Terry P. Kenakin.
Reminder of title:	theory, applications, and methods /
Author:	Kenakin, Terrence P.
Published:	Amsterdam ;Academic Press/Elsevier, : c2009.,
Description:	xix, 389 p. :ill. (some col.) ;29 cm.
[NT 15003449]:	What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
Subject:	Pharmacology, Experimental. -
Online resource:	http://www.sciencedirect.com/science/book/9780123745859An electronic book accessible through the World Wide Web; click for information
ISBN:	0123745853

A pharmacology primer = theory, applications, and methods /
Kenakin, Terrence P.

A pharmacology primertheory, applications, and methods /[electronic resource] :Terry P. Kenakin. - 3rd ed. - Amsterdam ;Academic Press/Elsevier,c2009. - xix, 389 p. :ill. (some col.) ;29 cm.

Includes bibliographical references and index.

What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.

This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments. The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles. Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.

Electronic reproduction.
Amsterdam :
Elsevier Science & Technology,
2009.

Mode of access: World Wide Web.

ISBN: 0123745853

Source: 158273:158442Elsevier Science & Technologyhttp://www.sciencedirect.comSubjects--Topical Terms:

812190
Pharmacology, Experimental.
Index Terms--Genre/Form:

542853
Electronic books.

LC Class. No.: RM301.25 / .K46 2009

Dewey Class. No.: 615/.7

National Library of Medicine Call No.: QV 38 / K33pg 2009

A pharmacology primer = theory, applications, and methods /
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005 20101126
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007 cr cn|||||||||
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020 $a 0123745853
020 $a 9780123745859
035 $a (OCoLC)318353777
035 $a ocn318353777
037 $a 158273:158442 $b Elsevier Science & Technology $n http://www.sciencedirect.com
040 $a OPELS $b eng $c OPELS
049 $a TEFA
050 1 4 $a RM301.25 $b .K46 2009
060 1 4 $a QV 38 $b K33pg 2009
082 0 4 $a 615/.7 $2 22
100 1 $a Kenakin, Terrence P. $3 1067713
245 1 2 $a A pharmacology primer $h [electronic resource] : $b theory, applications, and methods / $c Terry P. Kenakin.
250 $a 3rd ed.
260 $a Amsterdam ; $a Boston : $c c2009. $b Academic Press/Elsevier,
300 $a xix, 389 p. : $b ill. (some col.) ; $c 29 cm.
504 $a Includes bibliographical references and index.
505 0 $a What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
520 $a This successful guide assists scientists trained in molecular biology and related fields who now need to know the basic theories, principles and practical applications of pharmacology. This latest edition continues the tradition of better preparing researchers in the basics of pharmacology. With expanded hands-on exercises and the addition of Pharmacokinetics coverage, new human interest material including historical facts in pharmacology and a new section on therapeutics that will help readers identify with diseases and drug treatments. The ideal book for researchers in drug discovery who have seen their role shift from "individual" to "team player" where that team includes chemists, biologists, and others with strong, but varied, science backgrounds who must now work together toward their common pharmacology goal. New - Latest coverage of the chemistry of drugs including expanded coverage of the pharmacokinetic discussion of druglike properties -- Increases reader understanding of necessary ADME (Absorption, Distribution, Metabolism, and Excretion) properties and increases the rate of drug approval and acceptance. Context - Unique discussions on various drug discovery teams and the role of the chemist on those teams -- Promotes the understanding of these expanding roles and responsibilities and how to maximize the effective contributions of each matrix team member. Real-world learning - There are hands-on exercises, with extensive answers, utilizing real data on structure activity relationships; utilization of pharmacological principles to make general statements about how changes in structure lead to changes in drug activity. + hands on exercises with extensive answers on Pharmacokinetics -- Stengthens practical application and understanding of core concepts and principles. Study sections are organized with ASPET (American Society for Pharmacology and Experimental Therapeutics)and other international organizations -- Ensures that learning follows professional industry standards.
533 $a Electronic reproduction. $b Amsterdam : $c Elsevier Science & Technology, $d 2009. $n Mode of access: World Wide Web. $n System requirements: Web browser. $n Title from title screen (viewed on Apr. 10, 2009). $n Access may be restricted to users at subscribing institutions.
650 0 $a Pharmacology, Experimental. $3 812190
650 1 2 $a Receptors, Drug $x physiology. $3 1067714
650 2 2 $a Dose-Response Relationship, Drug. $3 754132
650 2 2 $a Pharmacology $x methods. $3 773559
655 7 $a Electronic books. $2 lcsh $3 542853
710 2 $a ScienceDirect (Online service) $3 848416
856 4 0 $3 ScienceDirect $u http://www.sciencedirect.com/science/book/9780123745859 $z An electronic book accessible through the World Wide Web; click for information
994 $a C0 $b TEF