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Omega-3 fatty acids and cognitive fu...

Tufts University, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy.

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Omega-3 fatty acids and cognitive function in the elderly.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Omega-3 fatty acids and cognitive function in the elderly./
Author:	Arsenault, Lisa N.
Description:	145 p.
Notes:	Adviser: Katherine L. Tucker.
Contained By:	Dissertation Abstracts International70-03B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3351927
ISBN:	9781109087253

Omega-3 fatty acids and cognitive function in the elderly.
Arsenault, Lisa N.

Omega-3 fatty acids and cognitive function in the elderly. - 145 p.

Adviser: Katherine L. Tucker.

Thesis (Ph.D.)--Tufts University, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, 2009.

The omega-3 fatty acids, EPA and DHA, have been shown to protect against incident dementia as well as decline in global cognition. However, studies within specific domains of cognitive function have been less consistent, and few have reported associations with structural indicators of underlying brain pathology. The aim of this thesis was to explore associations between the EPA+DHA, measures of domain-specific cognitive performance, and indicators of pathology on MRI scans. Additionally, we aimed to determine the validity of a food frequency questionnaire (FFQ) for estimating EPA+DHA intake in a population with prevalent cognitive impairment and dementia.

ISBN: 9781109087253Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Omega-3 fatty acids and cognitive function in the elderly.
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020 $a 9781109087253
035 $a (UMI)AAI3351927
035 $a AAI3351927
040 $a UMI $c UMI
100 1 $a Arsenault, Lisa N. $3 1065182
245 1 0 $a Omega-3 fatty acids and cognitive function in the elderly.
300 $a 145 p.
500 $a Adviser: Katherine L. Tucker.
500 $a Source: Dissertation Abstracts International, Volume: 70-03, Section: B, page: 1596.
502 $a Thesis (Ph.D.)--Tufts University, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, 2009.
520 $a The omega-3 fatty acids, EPA and DHA, have been shown to protect against incident dementia as well as decline in global cognition. However, studies within specific domains of cognitive function have been less consistent, and few have reported associations with structural indicators of underlying brain pathology. The aim of this thesis was to explore associations between the EPA+DHA, measures of domain-specific cognitive performance, and indicators of pathology on MRI scans. Additionally, we aimed to determine the validity of a food frequency questionnaire (FFQ) for estimating EPA+DHA intake in a population with prevalent cognitive impairment and dementia.
520 $a The FFQ was validated in 273 clinical study subjects using plasma phospholipid (PL) fatty acids as a biomarker of intake. Correlation coefficients (age- and energy-adjusted) indicated the FFQ was valid in estimating EPA+DHA intake (r=0.48). Furthermore, results were similar between the cognitively normal subjects, and those diagnosed with mild cognitive impairment or dementia (r=0.49, r=0.45, r=0.52, respectively).
520 $a Cognitive performance within specific domains of function was examined in 1,031 subjects. Dietary EPA+DHA was significantly associated with better memory function in men. Analysis of three individual memory tests indicated the protective effect was clinically relevant. No significant associations were observed with executive function or attention factors, or in women.
520 $a Using MRI data from 331 clinical subjects, a doubling of dietary EPA+DHA was significantly associated with 0.57% greater total brain volume and a doubling of PL DHA with 1.56% greater brain volume. Results were most consistent for cortical brain regions. Subjects with ≥ 1 large-vessel infarcts (LVI) on MRI had lower dietary (150 mg/day vs. 205 mg/day, P=0.063) and PL concentrations (2.88 mol% vs. 3.48 mol%, P=0.009) of EPA+DHA compared to those with no LVI.
520 $a In conclusion, we confirmed that interviewer-administered FFQ estimates of EPA+DHA intake are valid despite prevalent mild- to moderate-cognitive impairment. Our findings also suggest that these fatty acids, particularly DHA, may preserve cortical brain tissue, protect against large-vessel disease, and, in men, preserve memory function. Longitudinal work is needed to confirm these findings and to determine if the protective effects are disease specific or applicable to more general aspects of brain aging.
590 $a School code: 1546.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0317
690 $a 0570
710 2 $a Tufts University, Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy. $3 1065181
773 0 $t Dissertation Abstracts International $g 70-03B.
790 $a 1546
790 1 0 $a Tucker, Katherine L., $e advisor
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3351927