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Structural and functional perspectiv...

Arizona State University.

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Structural and functional perspectives of DNA directed self-assembly.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Structural and functional perspectives of DNA directed self-assembly./
Author:	Chhabra, Rahul.
Description:	226 p.
Notes:	Source: Dissertation Abstracts International, Volume: 70-03, Section: B, page: 1637.
Contained By:	Dissertation Abstracts International70-03B.
Subject:	Chemistry, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3351507
ISBN:	9781109077643

Structural and functional perspectives of DNA directed self-assembly.
Chhabra, Rahul.

Structural and functional perspectives of DNA directed self-assembly. - 226 p.

Source: Dissertation Abstracts International, Volume: 70-03, Section: B, page: 1637.

Thesis (Ph.D.)--Arizona State University, 2009.

Well known as a genetic material, Deoxyribonucleic acid (DNA) also possesses unique properties that make it an appealing building block to create self-assembled nanostructures. Ease of synthesis, predictable molecular recognition of base pairing and available chemical modifications all add to its significance as a structural entity. Through rational designs, researchers have constructed a wide range of DNA nanoarchitectures of predefined periodicities and complexities. This dissertation focuses on the functionalization of self-assembling DNA nanostructures. A tweezer-like DNA nanodevice was constructed such that it was fully addressable and acted in a well-controlled fashion. The device was used to actuate covalent coupling of tethered molecules, thus opening up possibilities to achieve a molecular assembly line in the future.

ISBN: 9781109077643Subjects--Topical Terms:

1021807
Chemistry, General.

Structural and functional perspectives of DNA directed self-assembly.
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245 1 0 $a Structural and functional perspectives of DNA directed self-assembly.
300 $a 226 p.
500 $a Source: Dissertation Abstracts International, Volume: 70-03, Section: B, page: 1637.
502 $a Thesis (Ph.D.)--Arizona State University, 2009.
520 $a Well known as a genetic material, Deoxyribonucleic acid (DNA) also possesses unique properties that make it an appealing building block to create self-assembled nanostructures. Ease of synthesis, predictable molecular recognition of base pairing and available chemical modifications all add to its significance as a structural entity. Through rational designs, researchers have constructed a wide range of DNA nanoarchitectures of predefined periodicities and complexities. This dissertation focuses on the functionalization of self-assembling DNA nanostructures. A tweezer-like DNA nanodevice was constructed such that it was fully addressable and acted in a well-controlled fashion. The device was used to actuate covalent coupling of tethered molecules, thus opening up possibilities to achieve a molecular assembly line in the future.
520 $a To demonstrate the organizational power of DNA nanostructures for self-assembly of multi-component and multi-functional nanomaterials, aptamer ligands were adapted to create multiprotein nanoarrays with deliberately designed patterns. DNA scaffolds were also utilized to control the positioning of metallic nanoparticles to form discrete as well as periodic patterns. New strategies were developed to enhance the metal-DNA affinity and to improve the yield of the final assembly. Furthermore, gold nanoparticles of different sizes were used to control the self-assembly of DNA nanotubes into various configurations. Potentially, self-assembling protein nanoarrays could be used to probe spatially dependent protein-protein and protein-ligand interactions. Efficient and robust self-assembly of nanoparticles into controlled patterns is crucial for fundamental understanding of particle-particle interactions.
590 $a School code: 0010.
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710 2 $a Arizona State University. $3 1017445
773 0 $t Dissertation Abstracts International $g 70-03B.
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791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3351507