東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Exogenous and endogenous chelating a...

Duke University.

Linked to FindBook

Google Book

Amazon

博客來

Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress./
Author:	Charkoudian, Louise K.
Description:	170 p.
Notes:	Adviser: Katherine J. Franz.
Contained By:	Dissertation Abstracts International70-02B.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3346755
ISBN:	9781109017922

Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress.
Charkoudian, Louise K.

Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress. - 170 p.

Adviser: Katherine J. Franz.

Thesis (Ph.D.)--Duke University, 2008.

A striking characteristic of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases is a localized increase in oxidative stress in the disease-affected region of the brain. The same regions that experience oxidative insult exhibit augmented iron loads, suggesting a central role of metal-catalyzed oxidative stress in pathogenesis. The hydroxyl radical, OH· , is a highly toxic radical that ensues from the interaction of redox-active metals, such as copper and iron, with hydrogen peroxide in biological systems. The oxidative stress induced by OH· is thought to be involved in the aging process and has been implicated in both neurodegeneration and macular degeneration.

ISBN: 9781109017922Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress.
LDR:03249nmm 2200301 a 45 001 890580
005 20101103
008 101103s2008 eng d
020 $a 9781109017922
035 $a (UMI)AAI3346755
035 $a AAI3346755
040 $a UMI $c UMI
100 1 $a Charkoudian, Louise K. $3 1064533
245 1 0 $a Exogenous and endogenous chelating agents for mitigating metal-promoted oxidative stress.
300 $a 170 p.
500 $a Adviser: Katherine J. Franz.
500 $a Source: Dissertation Abstracts International, Volume: 70-02, Section: B, page: 1014.
502 $a Thesis (Ph.D.)--Duke University, 2008.
520 $a A striking characteristic of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases is a localized increase in oxidative stress in the disease-affected region of the brain. The same regions that experience oxidative insult exhibit augmented iron loads, suggesting a central role of metal-catalyzed oxidative stress in pathogenesis. The hydroxyl radical, OH· , is a highly toxic radical that ensues from the interaction of redox-active metals, such as copper and iron, with hydrogen peroxide in biological systems. The oxidative stress induced by OH· is thought to be involved in the aging process and has been implicated in both neurodegeneration and macular degeneration.
520 $a Described here is the development of prochelators that have little affinity for metal ions until a protective mask is selectively removed by hydrogen peroxide to reveal a high affinity ligand that scavenges the redox-active metal. Whereas traditional iron chelators bind iron non-selectively, boronic ester prochelators bind iron only after exposure to hydrogen peroxide. The prochelator is designed to sequester potentially dangerous iron without competing with metal-essential proteins and altering healthy metal ion homeostasis. Spectroscopic characterization of several boronic ester prochelators reveals that the rate of unmasking by hydrogen peroxide, as well as the lipophilicity and strength of iron binding, can be tuned by modifications to the parent structure. The ability of the prochelators to inhibit hydroxyl radical formation in vitro was demonstrated by the deoxyribose assay. The protective effect of the prochelators against H2O2-induced cell death is demonstrated in a macular degeneration cell culture model.
520 $a The selective degeneration of dopaminergic neurons containing neuromelanin and concurrent elevation of iron concentrations in these neurons is a hallmark of Parkinson's disease. The final chapter discusses the characterization of Fe(III)-coordination properties of neuromelanin building blocks in aqueous solution by anaerobic pH-dependent spectrophotometric titrations. In aqueous solution at physiological pH, neuromelanin components leave open coordination sites on the iron center. Furthermore, oxidation studies reveal that iron accelerates the air oxidation of neuromelanin components.
590 $a School code: 0066.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Chemistry, Inorganic. $3 517253
690 $a 0487
690 $a 0488
710 2 0 $a Duke University. $3 569686
773 0 $t Dissertation Abstracts International $g 70-02B.
790 $a 0066
790 1 0 $a Franz, Katherine J., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3346755