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Mechanical response of the basilar m...

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Mechanical response of the basilar membrane to lateral micromanipulation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanical response of the basilar membrane to lateral micromanipulation./
Author:	Newburg, Seth O.
Description:	127 p.
Notes:	Adviser: David C. Mountain.
Contained By:	Dissertation Abstracts International70-01B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3345670
ISBN:	9781109004755

Mechanical response of the basilar membrane to lateral micromanipulation.
Newburg, Seth O.

Mechanical response of the basilar membrane to lateral micromanipulation. - 127 p.

Adviser: David C. Mountain.

Thesis (Ph.D.)--Boston University, 2009.

The stiffness and longitudinal coupling within the basilar membrane help shape the frequency tuning of the cochlea. For example, Naidu and Mountain (2001) proposed that longitudinal coupling in the basilar membrane could act to broaden the peak of the cochlear frequency response. In order to better characterize these mechanical properties, we made measurements of lateral point stiffness and longitudinal coupling in excised gerbil cochleae. An integrated optical imaging system and basilar membrane manipulator was devised in which a calibrated glass micropipette is used to displace the basilar membrane laterally. Because the tissue deformations occur in the optical plane of the microscope objective, detailed images of the movement of the micropipette tip and the basilar membrane microstructure were obtained. The tip motion was measured between sequential image pairs by two-dimensional cross-correlation, and was used to determine the force applied to the tissue. The lateral point stiffness in the arcuate zone is 0.2-0.5 N/m, in the pectinate zone is 2-3 N/m, and increases to over 10 N/m near the spiral ligament. These results suggest that the arcuate and pectiante zones have distinct material properties, which correspond to histologically observed differences in tissue morphology.

ISBN: 9781109004755Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Mechanical response of the basilar membrane to lateral micromanipulation.
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020 $a 9781109004755
035 $a (UMI)AAI3345670
035 $a AAI3345670
040 $a UMI $c UMI
100 1 $a Newburg, Seth O. $3 1058352
245 1 0 $a Mechanical response of the basilar membrane to lateral micromanipulation.
300 $a 127 p.
500 $a Adviser: David C. Mountain.
500 $a Source: Dissertation Abstracts International, Volume: 70-01, Section: B, page: 0459.
502 $a Thesis (Ph.D.)--Boston University, 2009.
520 $a The stiffness and longitudinal coupling within the basilar membrane help shape the frequency tuning of the cochlea. For example, Naidu and Mountain (2001) proposed that longitudinal coupling in the basilar membrane could act to broaden the peak of the cochlear frequency response. In order to better characterize these mechanical properties, we made measurements of lateral point stiffness and longitudinal coupling in excised gerbil cochleae. An integrated optical imaging system and basilar membrane manipulator was devised in which a calibrated glass micropipette is used to displace the basilar membrane laterally. Because the tissue deformations occur in the optical plane of the microscope objective, detailed images of the movement of the micropipette tip and the basilar membrane microstructure were obtained. The tip motion was measured between sequential image pairs by two-dimensional cross-correlation, and was used to determine the force applied to the tissue. The lateral point stiffness in the arcuate zone is 0.2-0.5 N/m, in the pectinate zone is 2-3 N/m, and increases to over 10 N/m near the spiral ligament. These results suggest that the arcuate and pectiante zones have distinct material properties, which correspond to histologically observed differences in tissue morphology.
520 $a To compute the longitudinal coupling, the displacement field in the tissue surrounding the probe was measured quantitatively using image registration. The displacement field was characterized by fitting exponential curves to the data along the longitudinal axis to find the lateral coupling space constants. The measurements show there is no trend for the space constants to be larger for tissue experiencing either compression or tension for applied displacements below 3 mum. The space constant increases with increased applied displacement, and linear regression was used to predict the space constant at displacements with physiologically realistic magnitude to be 3.6 mum.
520 $a A finite element model with simplified geometry was used to simulate the response of the BM to a lateral force applied in the plane of the BM. The model was evaluated with published values for the elastic constants of the gerbil BM (Liu and White, 2008). The simulated lateral point stiffness was in good agreement with the experimental data. The space constants of the displacement fields produced by the model were nearly ten times longer than those measured experimentally. An increased shear modulus or orthotropy ratio was required for the model to show realistic space constants.
590 $a School code: 0017.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biophysics, General. $3 1019105
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0433
690 $a 0541
690 $a 0786
710 2 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 70-01B.
790 $a 0017
790 1 0 $a Mountain, David C., $e advisor
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3345670