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Development of a novel magnetic sing...

University of Victoria (Canada).

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Development of a novel magnetic single cell micro array.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development of a novel magnetic single cell micro array./
Author:	Liu, William Wing Ning.
Description:	122 p.
Notes:	Source: Masters Abstracts International, Volume: 47-05, page: 2958.
Contained By:	Masters Abstracts International47-05.
Subject:	Biology, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR47309
ISBN:	9780494473092

Development of a novel magnetic single cell micro array.
Liu, William Wing Ning.

Development of a novel magnetic single cell micro array. - 122 p.

Source: Masters Abstracts International, Volume: 47-05, page: 2958.

Thesis (M.A.Sc.)--University of Victoria (Canada), 2008.

Single cell analysis techniques are valuable for revealing individual cell behaviour, which is of interest to many researchers. In such experiments, various types of devices capable of aligning cells into organized arrays are often used. Application of cell arrays reduces the cell-cell interaction during the experiment, allows parallel analysis of cells and facilitates the use of automated equipment. This thesis documents the development of a novel Magnetic Single Cell Micro Array (MSCMA), which makes use of magnetic force to array cells. The working principles, process of design, simulation and fabrication of the prototypes of the MSCMA are described. Prototypes of the MSCMA were successfully fabricated and tested using Jurkat cells that have been labelled with immunomagnetic labels. Experimental results show that the prototypes are effectively in capturing and arraying the cells labelled with immunomagnetic labels. In addition, tests using simple magnetic particles revealed the behaviour of the magnetic field created by the MSCMA, and matched the simulation results well. Although the prototypes suffered from some fabrication defects, these defects had little effect on the performance of the prototypes. Design changes to the MSCMA are proposed for future work, such as implementing a transparent substrate, and addressing the issues of fabrication defects.

ISBN: 9780494473092Subjects--Topical Terms:

1018625
Biology, General.

Development of a novel magnetic single cell micro array.
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100 1 $a Liu, William Wing Ning. $3 1057485
245 1 0 $a Development of a novel magnetic single cell micro array.
300 $a 122 p.
500 $a Source: Masters Abstracts International, Volume: 47-05, page: 2958.
502 $a Thesis (M.A.Sc.)--University of Victoria (Canada), 2008.
520 $a Single cell analysis techniques are valuable for revealing individual cell behaviour, which is of interest to many researchers. In such experiments, various types of devices capable of aligning cells into organized arrays are often used. Application of cell arrays reduces the cell-cell interaction during the experiment, allows parallel analysis of cells and facilitates the use of automated equipment. This thesis documents the development of a novel Magnetic Single Cell Micro Array (MSCMA), which makes use of magnetic force to array cells. The working principles, process of design, simulation and fabrication of the prototypes of the MSCMA are described. Prototypes of the MSCMA were successfully fabricated and tested using Jurkat cells that have been labelled with immunomagnetic labels. Experimental results show that the prototypes are effectively in capturing and arraying the cells labelled with immunomagnetic labels. In addition, tests using simple magnetic particles revealed the behaviour of the magnetic field created by the MSCMA, and matched the simulation results well. Although the prototypes suffered from some fabrication defects, these defects had little effect on the performance of the prototypes. Design changes to the MSCMA are proposed for future work, such as implementing a transparent substrate, and addressing the issues of fabrication defects.
590 $a School code: 0244.
650 4 $a Biology, General. $3 1018625
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
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710 2 0 $a University of Victoria (Canada). $3 1019404
773 0 $t Masters Abstracts International $g 47-05.
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