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Surface modification of luminescent ...

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Surface modification of luminescent nanoparticles: Enabling their use in biological imaging.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Surface modification of luminescent nanoparticles: Enabling their use in biological imaging./
Author:	Traina, Christopher Aaron.
Description:	133 p.
Notes:	Adviser: Jeffrey Schwartz.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3323198
ISBN:	9780549748021

Surface modification of luminescent nanoparticles: Enabling their use in biological imaging.
Traina, Christopher Aaron.

Surface modification of luminescent nanoparticles: Enabling their use in biological imaging. - 133 p.

Adviser: Jeffrey Schwartz.

Thesis (Ph.D.)--Princeton University, 2008.

Rare earth ion-doped Y2O3 nanoparticles are attractive for biological imaging applications due to their non-toxicity, resistance to photobleaching, and possibility for upconversion. Native, unmodified luminescent Y2O3 nanoparticles are not effective due to their propensity to aggregate in aqueous suspension and their lack of specificity for targeting in a biological context. A surface modification scheme based on organophosphonate monolayers was developed to enable the use of rare earth ion-doped nanoparticles as imaging probes. Nanoparticle suspendability properties could be adjusted by altering the hydrophobicity/hydrophilicity of the tail group of the surface-attached phosphonate. A modular approach to surface modification was used to achieve stability and aqueous suspendability. The first segment of the film provides hydrolytic stability; the second piece imparts aqueous suspendability; and, the final section affords biological specificity. This modular system was bio-compatible in in vitro tests, and was used to modify luminescent nanoparticles for in vitro imaging experiments. Peptide-conjugated nanoparticles demonstrated enhanced binding to cell surface receptors, and may show promise for use as probes for biological imaging.

ISBN: 9780549748021Subjects--Topical Terms:

517253
Chemistry, Inorganic.

Surface modification of luminescent nanoparticles: Enabling their use in biological imaging.
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100 1 $a Traina, Christopher Aaron. $3 1036382
245 1 0 $a Surface modification of luminescent nanoparticles: Enabling their use in biological imaging.
300 $a 133 p.
500 $a Adviser: Jeffrey Schwartz.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4172.
502 $a Thesis (Ph.D.)--Princeton University, 2008.
520 $a Rare earth ion-doped Y2O3 nanoparticles are attractive for biological imaging applications due to their non-toxicity, resistance to photobleaching, and possibility for upconversion. Native, unmodified luminescent Y2O3 nanoparticles are not effective due to their propensity to aggregate in aqueous suspension and their lack of specificity for targeting in a biological context. A surface modification scheme based on organophosphonate monolayers was developed to enable the use of rare earth ion-doped nanoparticles as imaging probes. Nanoparticle suspendability properties could be adjusted by altering the hydrophobicity/hydrophilicity of the tail group of the surface-attached phosphonate. A modular approach to surface modification was used to achieve stability and aqueous suspendability. The first segment of the film provides hydrolytic stability; the second piece imparts aqueous suspendability; and, the final section affords biological specificity. This modular system was bio-compatible in in vitro tests, and was used to modify luminescent nanoparticles for in vitro imaging experiments. Peptide-conjugated nanoparticles demonstrated enhanced binding to cell surface receptors, and may show promise for use as probes for biological imaging.
590 $a School code: 0181.
650 4 $a Chemistry, Inorganic. $3 517253
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710 2 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 69-07B.
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791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3323198