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The genetic contribution to ingestiv...

City University of New York., Psychology.

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The genetic contribution to ingestive processes: An inbred mouse strain survey.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The genetic contribution to ingestive processes: An inbred mouse strain survey./
Author:	Lewis-Levy, Sarah R.
Description:	187 p.
Notes:	Adviser: Richard J. Bodnar.
Contained By:	Dissertation Abstracts International69-10B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3330708
ISBN:	9780549861935

The genetic contribution to ingestive processes: An inbred mouse strain survey.
Lewis-Levy, Sarah R.

The genetic contribution to ingestive processes: An inbred mouse strain survey. - 187 p.

Adviser: Richard J. Bodnar.

Thesis (Ph.D.)--City University of New York, 2009.

Genetic variance in the consumption of sweet and bitter tastants as well as fat intake has been established through the use of inbred mouse strains. The use of limited ranges of strains, limited sets of concentrations, a failure to examine genetic variance for glucoprivic- or lipoprivic-induced intake formed the basis of this dissertation. The aims investigated whether 11 inbred (A/J, AKR/J, BALB/c/J, CBA/J, C3H/He/J, C57BL/6/J, C57BL/10/J, DBA/2/J, SWR/J and 129P3/J) and one outbred (CD-1) mouse strains differed in their intake of a wide concentration range of sucrose (0.0001-20%) or fat (Intralipid: 0.00001-5%) and intake (1-4 h) following the anti-metabolic glucose analogue, 2-deoxy-D-glucose (2DG: 200-800 mg/kg) or the free fatty acid oxidation inhibitor, mercaptoacetate (MA: 5-100 mg/kg).

ISBN: 9780549861935Subjects--Topical Terms:

1017730
Biology, Genetics.

The genetic contribution to ingestive processes: An inbred mouse strain survey.
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035 $a (UMI)AAI3330708
035 $a AAI3330708
040 $a UMI $c UMI
100 1 $a Lewis-Levy, Sarah R. $3 1036061
245 1 4 $a The genetic contribution to ingestive processes: An inbred mouse strain survey.
300 $a 187 p.
500 $a Adviser: Richard J. Bodnar.
500 $a Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: .
502 $a Thesis (Ph.D.)--City University of New York, 2009.
520 $a Genetic variance in the consumption of sweet and bitter tastants as well as fat intake has been established through the use of inbred mouse strains. The use of limited ranges of strains, limited sets of concentrations, a failure to examine genetic variance for glucoprivic- or lipoprivic-induced intake formed the basis of this dissertation. The aims investigated whether 11 inbred (A/J, AKR/J, BALB/c/J, CBA/J, C3H/He/J, C57BL/6/J, C57BL/10/J, DBA/2/J, SWR/J and 129P3/J) and one outbred (CD-1) mouse strains differed in their intake of a wide concentration range of sucrose (0.0001-20%) or fat (Intralipid: 0.00001-5%) and intake (1-4 h) following the anti-metabolic glucose analogue, 2-deoxy-D-glucose (2DG: 200-800 mg/kg) or the free fatty acid oxidation inhibitor, mercaptoacetate (MA: 5-100 mg/kg).
520 $a Sucrose intake was assessed across 9 concentrations using two-bottle tests controlling for concentration order, bottle positions, and kilocalorie intake consumed as sucrose. Strain specific differences were observed for the amounts and percentages of sucrose intake as well as for compensatory decreases in chow intake as sucrose concentrations increased. Sucrose intake correlated with previous data for saccharin intake and variants of the Tas1r3 taste receptor gene, particularly at lower concentrations.
520 $a To assess whether strain differences in fat intake were similar to those of sucrose intake, a highly similar methodology examined intake of Intralipid across 9 concentrations in the same strains. There were also clear and consistent strain differences across a wide range of measures for Intralipid intake. Interestingly, there were marked positive correlations in strain-specific intakes of sucrose and Intralipid.
520 $a Glucoprivic intakes were evaluated following systemic 2DG. Strain specific differences were observed in 2DG-induced feeding across different doses. A parallel study evaluating strain-specific lipoprivic intake used MA. Strain specific differences were also observed in MA-induced feeding. Correlations were generally not observed between lipoprivation and glucoprivation, lipoprivation and fat intake, and glucoprivation and sucrose intake, suggesting different mechanisms of action for observed genetic variance.
520 $a Together, the results of the four aims for this dissertation demonstrate a strong and distinct role for genetic variance in these four types of homeostatic ingestive responses that have implications for elucidating the genetic and environmental factors that may contribute to obesity.
590 $a School code: 0046.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Physiological. $3 1017869
690 $a 0317
690 $a 0369
690 $a 0989
710 2 $a City University of New York. $b Psychology. $3 1025517
773 0 $t Dissertation Abstracts International $g 69-10B.
790 $a 0046
790 1 0 $a Bodnar, Richard J. $e committee member
790 1 0 $a Bodnar, Richard J., $e advisor
790 1 0 $a Croll, Susan D. $e committee member
790 1 0 $a Glendinning, John I. $e committee member
790 1 0 $a Kest, Benjamin $e committee member
790 1 0 $a Sclafani, Anthony $e committee member
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3330708