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Monoliths and small particle-packed ...

State University of New York at Buffalo.

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Monoliths and small particle-packed columns for liquid chromatography .

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Monoliths and small particle-packed columns for liquid chromatography ./
作者:	Zhang, Xin.
面頁冊數:	153 p.
附註:	Adviser: Luis A. Colon.
Contained By:	Dissertation Abstracts International67-11B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3244236
ISBN:	9780542998232

Monoliths and small particle-packed columns for liquid chromatography .
Zhang, Xin.

Monoliths and small particle-packed columns for liquid chromatography . - 153 p.

Adviser: Luis A. Colon.

Thesis (Ph.D.)--State University of New York at Buffalo, 2007.

Advances in chromatography have led to two recent active areas of study: the reduction of particle size for column packing and development of monolithic materials. Reducing the size of the packing material leads to an increase in chromatographic efficiency and a decrease in the analysis time. The monolithic column is composed of one single piece of material with through-pores that offers very high permeability, thereby, allowing the column can offer a variable external porosity and operation at high linear velocity with low pressure requirements. The performance of commercially available columns, a monolith and a sub-2 mum particle packed column was examined. Higher efficiencies were obtained with the sub-2 mum particle packed column. Very high pressures 14,000 psi were required to operated the sub-2 mum packed column to obtain a linear velocity of 6.4 mm/sec, while a pressure of 1,600 psi was required to achieve a linear velocity of 12 mm/sec with the monolithic column. Examination by the van Deemter model shows that the monolithic column behaves like a 3 mum packed column.

ISBN: 9780542998232Subjects--Topical Terms:

586156
Chemistry, Analytical.

Monoliths and small particle-packed columns for liquid chromatography .
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245 1 0 $a Monoliths and small particle-packed columns for liquid chromatography .
300 $a 153 p.
500 $a Adviser: Luis A. Colon.
500 $a Source: Dissertation Abstracts International, Volume: 67-11, Section: B, page: 6372.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2007.
520 $a Advances in chromatography have led to two recent active areas of study: the reduction of particle size for column packing and development of monolithic materials. Reducing the size of the packing material leads to an increase in chromatographic efficiency and a decrease in the analysis time. The monolithic column is composed of one single piece of material with through-pores that offers very high permeability, thereby, allowing the column can offer a variable external porosity and operation at high linear velocity with low pressure requirements. The performance of commercially available columns, a monolith and a sub-2 mum particle packed column was examined. Higher efficiencies were obtained with the sub-2 mum particle packed column. Very high pressures 14,000 psi were required to operated the sub-2 mum packed column to obtain a linear velocity of 6.4 mm/sec, while a pressure of 1,600 psi was required to achieve a linear velocity of 12 mm/sec with the monolithic column. Examination by the van Deemter model shows that the monolithic column behaves like a 3 mum packed column.
520 $a A new approach to synthesize monolithic columns for capillary LC and capillary electrochromatography (CEC) was also examined. A silica based hybrid monolithic material was synthesized and characterized. The material fabricated inside capillary columns consisted of an allyl-functionalized monolith, which was prepared in a one-pot reaction. The material was characterized by SEM, nitrogen absorption (BET method), and chromatographically by CEC and CLC. The chromatographically tested column with best performance had a surface area of about 100 m2/g with through pores 7 mum and 6 nm mesopores.
520 $a A stationary phase for CEC was synthesized by polymerizing n-isopropylacrylamide on aminated silica particles. The poly-n-isopropylacrylamide was characterized by IR spectroscopy and thermogravimetric analysis. Both IR spectroscopy and thermogravimetric thermograms showed the grafting of the poly-n-isopropylacrylamide on the aminated silica. Tested under CEC conditions, using a series of neutral and acidic compounds, the stationary phase showed a mixed mode separation mechanism with both hydrophobicity and hydrophilicity contributing to the separation.
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791 $a Ph.D.
792 $a 2007
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