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Characterization of simian immunodef...

University of California, Davis.

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Characterization of simian immunodeficiency virus infection at the early stage of heterosexual transmission.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Characterization of simian immunodeficiency virus infection at the early stage of heterosexual transmission./
Author:	Ma, Zhong-Min.
Description:	187 p.
Notes:	Chair: Christopher J. Miller.
Contained By:	Dissertation Abstracts International69-09B.
Subject:	Agriculture, Animal Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3329645
ISBN:	9780549854289

Characterization of simian immunodeficiency virus infection at the early stage of heterosexual transmission.
Ma, Zhong-Min.

Characterization of simian immunodeficiency virus infection at the early stage of heterosexual transmission. - 187 p.

Chair: Christopher J. Miller.

Thesis (Ph.D.)--University of California, Davis, 2008.

Heterosexual transmission is the most common mode of human immune deficiency virus (HIV) transmission. Understanding the mechanism of HIV heterosexual transmission is the key for designing efficient strategies to control the HIV pandemic. To investigate the mechanism of HIV heterosexual transmission, we developed a multiple low-dose simian immune deficiency virus (SIV) vaginal inoculation model that mimics both the viral titer and exposure pattern of HIV heterosexual transmission, characterized the immunology and virology of SIV infection, especially at the early stage of the low-dose SIV inoculations. First, we found that typical SIV infection characterized by consistent viremia and sero-conversion can be induced by repeated low-dose SIV vaginal inoculation. Second, the virology and immunology dynamic of the typical SIV infection that induced by the low-dose inoculations was identical with the typical SIV infection induced by single high-dose SIV vaginal inoculation. Third, we found that transient viremia and limited SIV specific immune responses can be detected prior to the establishment of a typical SIV infection. Fourth, changes in the cytokine profile and the result that plasma transfer from plasma vRNA-SIV exposed monkeys can induce a typical SIV infection. Thus, atypical infection is common in monkeys that been vaginally exposed to low-dose SIV even though no vRNA and vDNA is found in blood and tissue samples. Last, plasma virus from the pre-ramp up and ramp up stages of acute SIV Infection have high infectivity. Along with common used single high-dose SIV vaginal inoculation model, the multiple low-dose SIV vaginal inoculation SIV model provide a tool for exploring the pathogenesis of SIV/HIV heterosexual transmission and testing the efficacy of vaccines and treatments including topic microbicides.

ISBN: 9780549854289Subjects--Topical Terms:

1021764
Agriculture, Animal Pathology.

Characterization of simian immunodeficiency virus infection at the early stage of heterosexual transmission.
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245 1 0 $a Characterization of simian immunodeficiency virus infection at the early stage of heterosexual transmission.
300 $a 187 p.
500 $a Chair: Christopher J. Miller.
500 $a Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: .
502 $a Thesis (Ph.D.)--University of California, Davis, 2008.
520 $a Heterosexual transmission is the most common mode of human immune deficiency virus (HIV) transmission. Understanding the mechanism of HIV heterosexual transmission is the key for designing efficient strategies to control the HIV pandemic. To investigate the mechanism of HIV heterosexual transmission, we developed a multiple low-dose simian immune deficiency virus (SIV) vaginal inoculation model that mimics both the viral titer and exposure pattern of HIV heterosexual transmission, characterized the immunology and virology of SIV infection, especially at the early stage of the low-dose SIV inoculations. First, we found that typical SIV infection characterized by consistent viremia and sero-conversion can be induced by repeated low-dose SIV vaginal inoculation. Second, the virology and immunology dynamic of the typical SIV infection that induced by the low-dose inoculations was identical with the typical SIV infection induced by single high-dose SIV vaginal inoculation. Third, we found that transient viremia and limited SIV specific immune responses can be detected prior to the establishment of a typical SIV infection. Fourth, changes in the cytokine profile and the result that plasma transfer from plasma vRNA-SIV exposed monkeys can induce a typical SIV infection. Thus, atypical infection is common in monkeys that been vaginally exposed to low-dose SIV even though no vRNA and vDNA is found in blood and tissue samples. Last, plasma virus from the pre-ramp up and ramp up stages of acute SIV Infection have high infectivity. Along with common used single high-dose SIV vaginal inoculation model, the multiple low-dose SIV vaginal inoculation SIV model provide a tool for exploring the pathogenesis of SIV/HIV heterosexual transmission and testing the efficacy of vaccines and treatments including topic microbicides.
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650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Virology. $3 1019068
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