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Quantitative, comparative toxicity a...

University of Illinois at Urbana-Champaign.

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Quantitative, comparative toxicity and toxicogenomic analyses of nitrogenous drinking water disinfection by-products.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Quantitative, comparative toxicity and toxicogenomic analyses of nitrogenous drinking water disinfection by-products./
Author:	Muellner, Mark G.
Description:	172 p.
Notes:	Adviser: Michael J. Plewa.
Contained By:	Dissertation Abstracts International69-05B.
Subject:	Engineering, Sanitary and Municipal. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3314856
ISBN:	9780549641704

Quantitative, comparative toxicity and toxicogenomic analyses of nitrogenous drinking water disinfection by-products.
Muellner, Mark G.

Quantitative, comparative toxicity and toxicogenomic analyses of nitrogenous drinking water disinfection by-products. - 172 p.

Adviser: Michael J. Plewa.

Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.

The disinfection of drinking water was perhaps the most important public health achievement of the 20th century. Drinking water disinfection by-products (DBPs) are an unintended consequence of a chemical reaction between natural and synthetic organic/inorganic materials in the source water and the particular disinfection method being utilized. Using calibrated microplate based mammalian cell assays we were able to utilize small quantities of synthesized DBP compounds and generate the world's largest quantitative, comparative, mammalian cell cytotoxicity and genotoxicity database. The particular focus of this dissertation was on nitrogen containing DBPs. Based on our previous results, bromoacetic acid, was utilized in a pioneering human toxicogenomic study. Normal, non-transformed human embryonic cells were used for this research and the cells were treated at a biologically relevant concentration of BAA that was at the lower limit of resolution of our genotoxicity assay. This toxicogenomic method, linked to a biological endpoint, defined bromoacetic acid as a non-threshold genotoxin and has led to the discovery that BAA-induced genotoxicity involves the generation of double strand DNA breaks. The work presented in this dissertation filled a large void in drinking water disinfection toxicity literature. This work serves as a foundation for future mechanistic toxicology of DBPs.

ISBN: 9780549641704Subjects--Topical Terms:

1018731
Engineering, Sanitary and Municipal.

Quantitative, comparative toxicity and toxicogenomic analyses of nitrogenous drinking water disinfection by-products.
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100 1 $a Muellner, Mark G. $3 1031099
245 1 0 $a Quantitative, comparative toxicity and toxicogenomic analyses of nitrogenous drinking water disinfection by-products.
300 $a 172 p.
500 $a Adviser: Michael J. Plewa.
500 $a Source: Dissertation Abstracts International, Volume: 69-05, Section: B, page: 2958.
502 $a Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008.
520 $a The disinfection of drinking water was perhaps the most important public health achievement of the 20th century. Drinking water disinfection by-products (DBPs) are an unintended consequence of a chemical reaction between natural and synthetic organic/inorganic materials in the source water and the particular disinfection method being utilized. Using calibrated microplate based mammalian cell assays we were able to utilize small quantities of synthesized DBP compounds and generate the world's largest quantitative, comparative, mammalian cell cytotoxicity and genotoxicity database. The particular focus of this dissertation was on nitrogen containing DBPs. Based on our previous results, bromoacetic acid, was utilized in a pioneering human toxicogenomic study. Normal, non-transformed human embryonic cells were used for this research and the cells were treated at a biologically relevant concentration of BAA that was at the lower limit of resolution of our genotoxicity assay. This toxicogenomic method, linked to a biological endpoint, defined bromoacetic acid as a non-threshold genotoxin and has led to the discovery that BAA-induced genotoxicity involves the generation of double strand DNA breaks. The work presented in this dissertation filled a large void in drinking water disinfection toxicity literature. This work serves as a foundation for future mechanistic toxicology of DBPs.
590 $a School code: 0090.
650 4 $a Engineering, Sanitary and Municipal. $3 1018731
650 4 $a Health Sciences, Toxicology. $3 1017752
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710 2 $a University of Illinois at Urbana-Champaign. $3 626646
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790 1 0 $a Plewa, Michael J., $e advisor
791 $a Ph.D.
792 $a 2008
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