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The effects of peripheral hyperchole...

Wayne State University., Nutrition and Food Science.

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The effects of peripheral hypercholesterolemia on brain cholesterol metabolism.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effects of peripheral hypercholesterolemia on brain cholesterol metabolism./
Author:	Yamada, Naomi.
Description:	176 p.
Notes:	Adviser: Pramod Khosla.
Contained By:	Dissertation Abstracts International68-09B.
Subject:	Gerontology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3277907
ISBN:	9780549189220

The effects of peripheral hypercholesterolemia on brain cholesterol metabolism.
Yamada, Naomi.

The effects of peripheral hypercholesterolemia on brain cholesterol metabolism. - 176 p.

Adviser: Pramod Khosla.

Thesis (Ph.D.)--Wayne State University, 2007.

We induced hypercholesterolemic condition in young, middle-aged, and old male Brown Norway rats by feeding cholesterol+cholic acid supplemented purified diet (CCA) for either short-term (1 month) or long-term (3-4 month).

ISBN: 9780549189220Subjects--Topical Terms:

533633
Gerontology.

The effects of peripheral hypercholesterolemia on brain cholesterol metabolism.
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020 $a 9780549189220
035 $a (UMI)AAI3277907
035 $a AAI3277907
040 $a UMI $c UMI
100 1 $a Yamada, Naomi. $3 1030945
245 1 4 $a The effects of peripheral hypercholesterolemia on brain cholesterol metabolism.
300 $a 176 p.
500 $a Adviser: Pramod Khosla.
500 $a Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5872.
502 $a Thesis (Ph.D.)--Wayne State University, 2007.
520 $a We induced hypercholesterolemic condition in young, middle-aged, and old male Brown Norway rats by feeding cholesterol+cholic acid supplemented purified diet (CCA) for either short-term (1 month) or long-term (3-4 month).
520 $a Disrupted cholesterol homeostasis in the brain and the peripheral circulation is associated with the etiology of Alzheimer's disease (AD). Since the brain's cholesterol metabolism is segregated, attenuated cholesterol metabolism in the AD brain is unlikely to be a direct consequence of elevated plasma cholesterol. Thus, we hypothesized that there should be signals derived from the peripheral circulation secondary to the chronic hypercholesterolemia that compromises normal brain metabolism.
520 $a The CCA created a "humanized" diet-induced hypercholesterolemia (DIH) in the peripheral compartment by significantly increasing total cholesterol in plasma and liver and shifting lipoprotein peaks from HDL to VLDL, while the brain's lipid profile was solely age-dependent. ELISA on the rat brain extracts showed that pathogenic Abeta42 increased whereas neuroprotective Abeta40 decreased with advancing age, and AD pathogenic factor Abeta42/40 ratio tended to be increased by DIH. Morris water maze test revealed age-related spatial learning decline, and the age effects were somewhat accelerated by DIH. Hippocampus microarray analysis revealed that the prolonged DIH in old rats was associated with >2-fold change in expression of >2000 probe sets.
520 $a These data suggest that the development of AD-like pathologies was age-dependent and it was accelerated by DIH. The DIH effects implicate the presence of the brain-body communication which mediates peripheral changes associated with DIH to the brain, thereby aggravating AD-like pathologies.
590 $a School code: 0254.
650 4 $a Gerontology. $3 533633
650 4 $a Health Sciences, Nutrition. $3 1017801
690 $a 0351
690 $a 0570
710 2 $a Wayne State University. $b Nutrition and Food Science. $3 1030944
773 0 $t Dissertation Abstracts International $g 68-09B.
790 $a 0254
790 1 0 $a Coscina, Donald V. $e committee member
790 1 0 $a Heydari, Ahmad $e committee member
790 1 0 $a Jen, Catherine K-L $e committee member
790 1 0 $a Khosla, Pramod, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3277907