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Structure, ordering, and activity of...

The University of Chicago.

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Structure, ordering, and activity of lipid/polymer systems.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Structure, ordering, and activity of lipid/polymer systems./
作者:	Frey, Shelli Lynne.
面頁冊數:	373 p.
附註:	Adviser: Ka Yee C. Lee.
Contained By:	Dissertation Abstracts International69-07B.
標題:	Chemistry, Physical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3322585
ISBN:	9780549740292

Structure, ordering, and activity of lipid/polymer systems.
Frey, Shelli Lynne.

Structure, ordering, and activity of lipid/polymer systems. - 373 p.

Adviser: Ka Yee C. Lee.

Thesis (Ph.D.)--The University of Chicago, 2008.

Lipid-lipid, lipid-polymer, lipid-peptide interactions in model cell membranes were characterized to pinpoint how variations in molecular architecture affect subsequent ordering, inducement of structures, and activity of these different mixtures. Lipid monolayers, at the air/water interface and also deposited on solid supports, served as models for the cell membrane outer leaflet and were probed with surface pressure versus area isotherms, fluorescence microscopy, atomic force microscopy, and also X-ray scattering techniques.

ISBN: 9780549740292Subjects--Topical Terms:

560527
Chemistry, Physical.

Structure, ordering, and activity of lipid/polymer systems.
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245 1 0 $a Structure, ordering, and activity of lipid/polymer systems.
300 $a 373 p.
500 $a Adviser: Ka Yee C. Lee.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4190.
502 $a Thesis (Ph.D.)--The University of Chicago, 2008.
520 $a Lipid-lipid, lipid-polymer, lipid-peptide interactions in model cell membranes were characterized to pinpoint how variations in molecular architecture affect subsequent ordering, inducement of structures, and activity of these different mixtures. Lipid monolayers, at the air/water interface and also deposited on solid supports, served as models for the cell membrane outer leaflet and were probed with surface pressure versus area isotherms, fluorescence microscopy, atomic force microscopy, and also X-ray scattering techniques.
520 $a Interactions of triblock copolymers, known to be healing agents for electroporated cells, with lipid monolayers were characterized with conventional lipid monolayer methods and Monte Carlo simulations. Factors such as temperature, size of polymer blocks, and the hydrophilic:hydrophobic ratio affect polymer solubility in both the subphase and the membrane suggesting a degree of tunability for biomedical applications involving polymer incorporation into lipid membranes.
520 $a A subset of glycolipids, gangliosides, known to partition into lipid rafts, or ordered portions of the cell membrane, were shown to influence the phase behavior of neighboring lipids, causing a condensation of the layer at low mol% followed by fluidization with further addition of ganglioside. This effect is attributed to the wedge-shaped geometry of the ganglioside headgroup that forms a geometric close-packed complex with the surrounding phospholipid. The structure of gangliosides and induced organization in both monolayers and vesicles mediate amyloid beta fibril formation and subsequent membrane disruption implicated in Alzheimer's disease.
520 $a Using different ratios of components in the binary lipid/ganglioside system to create membranes with systematically varying material properties, we show that membrane fluidity affects the monolayer reaction to lateral compression; a general criterion has been developed dictating whether a lipid monolayer folds into the third dimension at high surface compressions.
520 $a The molecular architecture and flexibility of lung surfactant truncation peptide B affects its activity in model pulmonary surfactant with the N-terminal insertion sequence essential to support formation of three-dimensional reversible repositories of collapsed materials necessary for proper lung function at high surface pressures. Structure was also implicated in monolayer ordering when compressed binary mixtures of lipid and polymer at specific mole ratios are expanded though a labyrinthine transition that occurs at vanishing surface pressure.
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650 4 $a Chemistry, Polymer. $3 1018428
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790 1 0 $a Lee, Ka Yee C., $e advisor
791 $a Ph.D.
792 $a 2008
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