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VE-cadherin and vascular dysfunction...

The University of New Mexico.

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VE-cadherin and vascular dysfunction in Diabetic Retinopathy.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	VE-cadherin and vascular dysfunction in Diabetic Retinopathy./
作者:	Navaratna, Deepti.
面頁冊數:	152 p.
附註:	Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3525.
Contained By:	Dissertation Abstracts International69-06B.
標題:	Health Sciences, Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3318106
ISBN:	9780549677451

VE-cadherin and vascular dysfunction in Diabetic Retinopathy.
Navaratna, Deepti.

VE-cadherin and vascular dysfunction in Diabetic Retinopathy. - 152 p.

Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3525.

Thesis (Ph.D.)--The University of New Mexico, 2008.

This dissertation describes a novel regulatory pathway for increased microvascular permeability in the diabetic retina. Breakdown of the blood-retinal barrier (BRB) is a central event in the progression of Diabetic Retinopathy (DR). In Chapters 2 and 3, we demonstrate that the proteolytic degradation of vascular endothelial cadherin (VEcadherin) by matrix metalloproteinases (MMPs) might be a novel mechanism by which the blood-retinal barrier is altered in diabetes and that VE-cadherin engagement is a major determinant of retinal permeability. In chapter 4, the role of VE-cadherin in the cellular events preceding angiogenesis such as cell migration, proliferation and tubule formation was investigated. This study identifies VE-cadherin as a potential target for therapeutic intervention in proliferative diabetic retinopathy.

ISBN: 9780549677451Subjects--Topical Terms:

1019544
Health Sciences, Epidemiology.

VE-cadherin and vascular dysfunction in Diabetic Retinopathy.
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520 $a This dissertation describes a novel regulatory pathway for increased microvascular permeability in the diabetic retina. Breakdown of the blood-retinal barrier (BRB) is a central event in the progression of Diabetic Retinopathy (DR). In Chapters 2 and 3, we demonstrate that the proteolytic degradation of vascular endothelial cadherin (VEcadherin) by matrix metalloproteinases (MMPs) might be a novel mechanism by which the blood-retinal barrier is altered in diabetes and that VE-cadherin engagement is a major determinant of retinal permeability. In chapter 4, the role of VE-cadherin in the cellular events preceding angiogenesis such as cell migration, proliferation and tubule formation was investigated. This study identifies VE-cadherin as a potential target for therapeutic intervention in proliferative diabetic retinopathy.
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