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Inflammatory role of the chondrocyte...

Universiteit Antwerpen (Belgium).

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Inflammatory role of the chondrocyte: Influence of bisphosphonates and statins.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Inflammatory role of the chondrocyte: Influence of bisphosphonates and statins./
Author:	Dombrecht, Evelyne J.
Description:	144 p.
Notes:	Adviser: L. S. De Clerck.
Contained By:	Dissertation Abstracts International68-02B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3251210

Inflammatory role of the chondrocyte: Influence of bisphosphonates and statins.
Dombrecht, Evelyne J.

Inflammatory role of the chondrocyte: Influence of bisphosphonates and statins. - 144 p.

Adviser: L. S. De Clerck.

Thesis (Ph.D.)--Universiteit Antwerpen (Belgium), 2007.

Rheumatoid arthritis (RA) is a chronic auto-immune disease characterized by joint destruction. It is generally accepted that pro-inflammatory cytokines and reactive oxygen species (ROS) play a pivotal role in the pathogenesis of RA. In response to these proinflammatory mediators, chondrocytes, which in normal physiological conditions are responsible for the cartilage matrix homeostasis, can synthesize and release themselves several mediators such as pro-inflammatory cytokines, metalloproteinases and ROS which contribute to cartilage destruction.Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Inflammatory role of the chondrocyte: Influence of bisphosphonates and statins.
LDR:03279nam 2200289 a 45 001 858157
005 20100712
008 100712s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI3251210
035 $a AAI3251210
040 $a UMI $c UMI
100 1 $a Dombrecht, Evelyne J. $3 1025188
245 1 0 $a Inflammatory role of the chondrocyte: Influence of bisphosphonates and statins.
300 $a 144 p.
500 $a Adviser: L. S. De Clerck.
500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0875.
502 $a Thesis (Ph.D.)--Universiteit Antwerpen (Belgium), 2007.
520 $a Rheumatoid arthritis (RA) is a chronic auto-immune disease characterized by joint destruction. It is generally accepted that pro-inflammatory cytokines and reactive oxygen species (ROS) play a pivotal role in the pathogenesis of RA. In response to these proinflammatory mediators, chondrocytes, which in normal physiological conditions are responsible for the cartilage matrix homeostasis, can synthesize and release themselves several mediators such as pro-inflammatory cytokines, metalloproteinases and ROS which contribute to cartilage destruction.
520 $a As compared to the general population, patients with RA have a higher prevalence of osteoporosis. Bisphosphonates are useful in the prevention and treatment of glucocorticoid induced osteoporosis in patients with RA. Moreover, data indicate that bisphosphonates have potent anti-inflammatory effects. Another class of drugs, namely the statins, have been proven to possess anti-inflammatory characteristics. Statins are widely used as cholesterol lowering drugs and for the prevention and treatment of cardiovascular diseases. Moreover, cardiovascular diseases represent a major cause in the higher mortality rates observed in patients with RA. These data indicate that bisphosphonates and/or statins may have different modes of actions in RA: a positive effect on extra-articular complications as well as anti-inflammatory and consequently joint protective effects.
520 $a Currently little is known about the direct effect of bisphosphonates and statins on the articular cartilage. The objective of the present work was primarily to investigate the influence of bisphosphonates and additionally also of simvastatin, a widely used statin, on chondrocyte function.
520 $a This thesis provides evidence for anti-inflammatory effects of bisphosphonates and statins in RA. However, the effects of these two class of drugs on chondrocytes are different: bisphosphonates mainly act as antioxidants due to their iron chelating characteristics while simvastatin has anti-inflammatory effects predominantly by reducing IL-6 and IL-8 production and to a lesser extent by inhibiting NO production and chondrocyte lipid peroxidation. Taken together, these results indicate that both drugs, together with their potential to reduce important extra-articular complications and their relative safe profile, can have cartilage protective effects in rheumatic diseases.
590 $a School code: 1513.
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0982
710 2 $a Universiteit Antwerpen (Belgium). $3 1023974
773 0 $t Dissertation Abstracts International $g 68-02B.
790 $a 1513
790 1 0 $a De Clerck, L. S., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3251210