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Further characterization of the reti...

Michigan State University.

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Further characterization of the retinopathy, globe enlarged (rge) chicken.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Further characterization of the retinopathy, globe enlarged (rge) chicken./
Author:	Shaw, Gillian Curtis.
Description:	153 p.
Notes:	Adviser: Simon M. Petersen-Jones.
Contained By:	Masters Abstracts International46-02.
Subject:	Health Sciences, Ophthalmology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1448528
ISBN:	9780549254973

Further characterization of the retinopathy, globe enlarged (rge) chicken.
Shaw, Gillian Curtis.

Further characterization of the retinopathy, globe enlarged (rge) chicken. - 153 p.

Adviser: Simon M. Petersen-Jones.

Thesis (M.S.)--Michigan State University, 2007.

Previous work has shown that retinopathy, globe enlarged (rge) affected chicks eventually become functionally blind and subsequently develop globe enlargement. Electroretinographic (ERG) abnormalities include increased thresholds, a "supernormal b-wave" in response to brighter flashes, a lack of oscillatory potentials and ERG responses that are present long after functional blindness. Screening of several positional candidate genes was performed; however, another research group identified the causative mutation in GNB3, the beta subunit of a heterotrimeric G-protein involved in phototransduction in cone photoreceptors. Pharmacological dissection of the rge ERG using aspartate, APB and PDA demonstrated decreased cone sensitivity but also suggested abnormalities of the inner retinal ON and OFF pathways. GNB3 has not definitively been shown to be involved in inner retinal pathways, however these ERG results suggest it may play a role in such pathways. Preliminary immunohistochemistry identified GNB3 immunoreactivity in cone cell bodies, outer plexiform layer synaptic terminals and a population of cells in the inner nuclear and ganglion cell layers in normal chicken retina. These data suggest GNB3 may also be important in inner retinal signaling. Further studies are necessary to explore this hypothesis.

ISBN: 9780549254973Subjects--Topical Terms:

1019445
Health Sciences, Ophthalmology.

Further characterization of the retinopathy, globe enlarged (rge) chicken.
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005 20100708
008 100708s2007 ||||||||||||||||| ||eng d
020 $a 9780549254973
035 $a (UMI)AAI1448528
035 $a AAI1448528
040 $a UMI $c UMI
100 1 $a Shaw, Gillian Curtis. $3 1021885
245 1 0 $a Further characterization of the retinopathy, globe enlarged (rge) chicken.
300 $a 153 p.
500 $a Adviser: Simon M. Petersen-Jones.
500 $a Source: Masters Abstracts International, Volume: 46-02, page: 0936.
502 $a Thesis (M.S.)--Michigan State University, 2007.
520 $a Previous work has shown that retinopathy, globe enlarged (rge) affected chicks eventually become functionally blind and subsequently develop globe enlargement. Electroretinographic (ERG) abnormalities include increased thresholds, a "supernormal b-wave" in response to brighter flashes, a lack of oscillatory potentials and ERG responses that are present long after functional blindness. Screening of several positional candidate genes was performed; however, another research group identified the causative mutation in GNB3, the beta subunit of a heterotrimeric G-protein involved in phototransduction in cone photoreceptors. Pharmacological dissection of the rge ERG using aspartate, APB and PDA demonstrated decreased cone sensitivity but also suggested abnormalities of the inner retinal ON and OFF pathways. GNB3 has not definitively been shown to be involved in inner retinal pathways, however these ERG results suggest it may play a role in such pathways. Preliminary immunohistochemistry identified GNB3 immunoreactivity in cone cell bodies, outer plexiform layer synaptic terminals and a population of cells in the inner nuclear and ganglion cell layers in normal chicken retina. These data suggest GNB3 may also be important in inner retinal signaling. Further studies are necessary to explore this hypothesis.
590 $a School code: 0128.
650 4 $a Health Sciences, Ophthalmology. $3 1019445
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0381
690 $a 0571
710 2 $a Michigan State University. $3 676168
773 0 $t Masters Abstracts International $g 46-02.
790 $a 0128
790 1 0 $a Petersen-Jones, Simon M., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1448528