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Hazardous air pollutants and childho...

The University of Texas School of Public Health., Epidemiology & Disease Control.

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Hazardous air pollutants and childhood lymphohematopoietic cancer in Southeast Texas, 1995--2004.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Hazardous air pollutants and childhood lymphohematopoietic cancer in Southeast Texas, 1995--2004./
作者:	Whitworth, Kristina Walker.
面頁冊數:	78 p.
附註:	Adviser: Elaine Symanski.
Contained By:	Dissertation Abstracts International70-03B.
標題:	Atmospheric Sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoeng/servlet/advanced?query=3350195
ISBN:	9781109073218

Hazardous air pollutants and childhood lymphohematopoietic cancer in Southeast Texas, 1995--2004.
Whitworth, Kristina Walker.

Hazardous air pollutants and childhood lymphohematopoietic cancer in Southeast Texas, 1995--2004. - 78 p.

Adviser: Elaine Symanski.

Thesis (Ph.D.)--The University of Texas School of Public Health, 2009.

Southeast Texas, including Houston, has a large presence of industrial facilities and has been documented to have poorer air quality and significantly higher cancer rates than the remainder of Texas. Given citizens' concerns in this 4th largest city in the U.S., Mayor Bill White recently partnered with the UT School of Public Health to determine methods to evaluate the health risks of hazardous air pollutants (HAPs). Sexton et al. (2007) published a report that strongly encouraged analytic studies linking these pollutants with health outcomes. In response, we set out to complete the following aims: 1. determine the optimal exposure assessment strategy to assess the association between childhood cancer rates and increased ambient levels of benzene and 1,3-butadiene (in an ecologic setting) and 2. evaluate whether census tracts with the highest levels of benzene or 1,3-butadiene have higher incidence of childhood lymphohematopoietic cancer compared with census tracts with the lowest levels of benzene or 1,3-butadiene, using Poisson regression. The first aim was achieved by evaluating the usefulness of four data sources: geographic information systems (GIS) to identify proximity to point sources of industrial air pollution, industrial emission data from the U.S. EPA's Toxic Release Inventory (TRI), routine monitoring data from the U.S. EPA Air Quality System (AQS) from 1999-2000 and modeled ambient air levels from the U.S. EPA's 1999 National Air Toxic Assessment Project (NATA) ASPEN model. Further, once these four data sources were evaluated, we narrowed them down to two: the routine monitoring data from the AQS for the years 1998-2000 and the 1999 U.S. EPA NATA ASPEN modeled data. We applied kriging (spatial interpolation) methodology to the monitoring data and compared the kriged values to the ASPEN modeled data. Our results indicated poor agreement between the two methods. Relative to the U.S. EPA ASPEN modeled estimates, relying on kriging to classify census tracts into exposure groups would have caused a great deal of misclassification. To address the second aim, we additionally obtained childhood lymphohematopoietic cancer data for 1995-2004 from the Texas Cancer Registry. The U.S. EPA ASPEN modeled data were used to estimate ambient levels of benzene and 1,3-butadiene in separate Poisson regression analyses. All data were analyzed at the census tract level. We found that census tracts with the highest benzene levels had elevated rates of all leukemia (rate ratio (RR) = 1.37; 95% confidence interval (CI), 1.05-1.78). Among census tracts with the highest 1,3-butadiene levels, we observed RRs of 1.40 (95% CI, 1.07-1.81) for all leukemia. We detected no associations between benzene or 1,3-butadiene levels and childhood lymphoma incidence. This study is the first to examine this association in Harris and surrounding counties in Texas and is among the first to correlate monitored levels of HAPs with childhood lymphohematopoietic cancer incidence, evaluating several analytic methods in an effort to determine the most appropriate approach to test this association. Despite recognized weakness of ecologic analyses, our analysis suggests an association between childhood leukemia and hazardous air pollution.

ISBN: 9781109073218Subjects--Topical Terms:

1019179
Atmospheric Sciences.

Hazardous air pollutants and childhood lymphohematopoietic cancer in Southeast Texas, 1995--2004.
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