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DNA templated magnetic nanoparticles.

Purdue University., Biomedical Engineering.

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DNA templated magnetic nanoparticles.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	DNA templated magnetic nanoparticles./
Author:	Kinsella, Joseph M.
Description:	131 p.
Notes:	Adviser: Albena Ivanisevic.
Contained By:	Dissertation Abstracts International69-04B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309276
ISBN:	9780549571339

DNA templated magnetic nanoparticles.
Kinsella, Joseph M.

DNA templated magnetic nanoparticles. - 131 p.

Adviser: Albena Ivanisevic.

Thesis (Ph.D.)--Purdue University, 2007.

Recent discoveries in nanoscience are predicted to potentially revolutionize future technologies in an extensive number of fields. These developments are contingent upon discovering new and often unconventional methods to synthesize and control nanoscale components. Nature provides several examples of working nanotechnology such as the use of programmed self assembly to build and deconstruct complex molecular systems. We have adopted a method to control the one dimensional assembly of magnetic nanoparticles using DNA as a scaffold molecule. With this method we have demonstrated the ability to organize 5 nm particles into chains that stretch up to &sim;20 mum in length. One advantage of using DNA compared is the ability of the molecule to interact with other biomolecules. After assembling particles onto DNA we have been able to cleave the molecule into smaller fragments using restriction enzymes. Using ligase enzymes we have re-connected these fragments, coated with either gold or iron oxide, to form long one-dimensional arrangements of the two different types of nanoparticles on a single molecular guide. We have also created a sensitive magnetic field sensor by incorporating magnetic nanoparticle coated DNA strands with microfabricated electrodes. The IV characteristics of the aligned nanoparticles are dependant on the magnitude of an externally applied magnetic field. This transport phenomenon known as tunneling magnetoresistance (TMR) shows room temperature resistance of our devices over 80% for cobalt ferrite coated DNA when a field of 20 kOe is applied. In comparison, studies using two dimensional nanoparticle films of irox oxides xii only exhibit a 35% MR effect. Confinement into one dimension using the DNA guide produces a TMR mechanism which produces significant increases in magnetoresistance. This property can be utilized for applications in magnetic field sensing, data storage, and logic elements.

ISBN: 9780549571339Subjects--Topical Terms:

517253
Chemistry, Inorganic.

DNA templated magnetic nanoparticles.
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020 $a 9780549571339
035 $a (UMI)AAI3309276
035 $a AAI3309276
040 $a UMI $c UMI
100 1 $a Kinsella, Joseph M. $3 1019123
245 1 0 $a DNA templated magnetic nanoparticles.
300 $a 131 p.
500 $a Adviser: Albena Ivanisevic.
500 $a Source: Dissertation Abstracts International, Volume: 69-04, Section: B, page: 2456.
502 $a Thesis (Ph.D.)--Purdue University, 2007.
520 $a Recent discoveries in nanoscience are predicted to potentially revolutionize future technologies in an extensive number of fields. These developments are contingent upon discovering new and often unconventional methods to synthesize and control nanoscale components. Nature provides several examples of working nanotechnology such as the use of programmed self assembly to build and deconstruct complex molecular systems. We have adopted a method to control the one dimensional assembly of magnetic nanoparticles using DNA as a scaffold molecule. With this method we have demonstrated the ability to organize 5 nm particles into chains that stretch up to &sim;20 mum in length. One advantage of using DNA compared is the ability of the molecule to interact with other biomolecules. After assembling particles onto DNA we have been able to cleave the molecule into smaller fragments using restriction enzymes. Using ligase enzymes we have re-connected these fragments, coated with either gold or iron oxide, to form long one-dimensional arrangements of the two different types of nanoparticles on a single molecular guide. We have also created a sensitive magnetic field sensor by incorporating magnetic nanoparticle coated DNA strands with microfabricated electrodes. The IV characteristics of the aligned nanoparticles are dependant on the magnitude of an externally applied magnetic field. This transport phenomenon known as tunneling magnetoresistance (TMR) shows room temperature resistance of our devices over 80% for cobalt ferrite coated DNA when a field of 20 kOe is applied. In comparison, studies using two dimensional nanoparticle films of irox oxides xii only exhibit a 35% MR effect. Confinement into one dimension using the DNA guide produces a TMR mechanism which produces significant increases in magnetoresistance. This property can be utilized for applications in magnetic field sensing, data storage, and logic elements.
590 $a School code: 0183.
650 4 $a Chemistry, Inorganic. $3 517253
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Materials Science. $3 1017759
690 $a 0488
690 $a 0541
690 $a 0794
710 2 $a Purdue University. $b Biomedical Engineering. $3 1019122
773 0 $t Dissertation Abstracts International $g 69-04B.
790 $a 0183
790 1 0 $a Bashir, Rashid $e committee member
790 1 0 $a Harris, Michael $e committee member
790 1 0 $a Ivanisevic, Albena, $e advisor
790 1 0 $a Shalaev, Vladimir $e committee member
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3309276