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Lucilia sericata development: Plasti...

Michigan State University.

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Lucilia sericata development: Plasticity, population differences, and gene expression.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Lucilia sericata development: Plasticity, population differences, and gene expression./
Author:	Tarone, Aaron Michael.
Description:	248 p.
Notes:	Adviser: David R. Foran.
Contained By:	Dissertation Abstracts International68-05B.
Subject:	Biology, Entomology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3264244
ISBN:	9780549027997

Lucilia sericata development: Plasticity, population differences, and gene expression.
Tarone, Aaron Michael.

Lucilia sericata development: Plasticity, population differences, and gene expression. - 248 p.

Adviser: David R. Foran.

Thesis (Ph.D.)--Michigan State University, 2007.

Blow flies (Diptera: Calliphoridae) are parasitoids, parasites, and primary successional species on carrion. A detailed understanding of their development can impact medical, veterinary, and forensic sciences as they spread disease, debride wounds, spoil food, parasitize humans and livestock, and predictably develop on carrion. Comparisons of blow flies to Drosophila melanogaster and other higher flies can also reveal important evolutionary effects on a locus or trait of interest. The research detailed herein was based on the application of quantitative and molecular genetic methodology to questions regarding the development of the globally distributed blow fly Lucilia sericata (Diptera: Calliphoridae) (Meigen).

ISBN: 9780549027997Subjects--Topical Terms:

1018619
Biology, Entomology.

Lucilia sericata development: Plasticity, population differences, and gene expression.
LDR:04155nam 2200301 a 45 001 852657
005 20100630
008 100630s2007 ||||||||||||||||| ||eng d
020 $a 9780549027997
035 $a (UMI)AAI3264244
035 $a AAI3264244
040 $a UMI $c UMI
100 1 $a Tarone, Aaron Michael. $3 1018635
245 1 0 $a Lucilia sericata development: Plasticity, population differences, and gene expression.
300 $a 248 p.
500 $a Adviser: David R. Foran.
500 $a Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 2779.
502 $a Thesis (Ph.D.)--Michigan State University, 2007.
520 $a Blow flies (Diptera: Calliphoridae) are parasitoids, parasites, and primary successional species on carrion. A detailed understanding of their development can impact medical, veterinary, and forensic sciences as they spread disease, debride wounds, spoil food, parasitize humans and livestock, and predictably develop on carrion. Comparisons of blow flies to Drosophila melanogaster and other higher flies can also reveal important evolutionary effects on a locus or trait of interest. The research detailed herein was based on the application of quantitative and molecular genetic methodology to questions regarding the development of the globally distributed blow fly Lucilia sericata (Diptera: Calliphoridae) (Meigen).
520 $a The main focus of this research was to improve the precision of postmortem interval (PMI) estimates produced with entomological evidence, based on the inclusion of developmentally variable gene expression data into the process of predicting blow fly age. The expression profiles of 9 genes, in conjunction with generalized additive models (GAMS), was useful in more precisely predicting the ages of immature L. sericata. Some genes were also useful in identifying individuals in a state of arrested development, which will further decrease error in entomology based PMI estimates.
520 $a The principles of quantitative genetics were also applied to the problem of understanding developmental variation in L. sericata. Complimentary studies were undertaken to understand how the environment and genetics affect body size and development time. Components of developmental plasticity were identified, providing an improved understanding of how laboratory rearing conditions affect blow fly development time and enabling the identification of a rearing protocol that mimics growth on carrion. Likewise, the effects of genotype and temperature on variation in the development time and body sizes of L. sericata from California, Michigan, and West Virginia were determined, revealing significant temperature and strain effects on these phenotypes.
520 $a The results of these projects indicate that molecular and quantitative genetics are useful tools in understanding blow fly development, especially for predicting a PMI. The approach used herein demonstrated a quantifiably improved ability to predict blow fly age, addressing a key shortcoming in forensic entomology as interpreted by the Daubert standard of scientific evidence. However, the data obtained will also be useful in devising methodologies for controlling blow fly populations and in understanding the evolution of development. Several of the genes studied interact with insecticides; consequently, profiles of the expression levels of these genes can be useful for controlling blow fly pests. Similarly, knowledge about the factors affecting developmental plasticity may be used to better manage facilities affected by blow flies. Likewise, the high-resolution gene expression data produced in this research will aid in understanding the evolution of development in the Diptera. By studying gene expression, and other traits, throughout the development of the blow fly Lucilia sericata, valuable knowledge affecting a variety of biological studies has been acquired.
590 $a School code: 0128.
650 4 $a Biology, Entomology. $3 1018619
690 $a 0353
710 2 $a Michigan State University. $3 676168
773 0 $t Dissertation Abstracts International $g 68-05B.
790 $a 0128
790 1 0 $a Foran, David R., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3264244