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PLA-PEO-PLA triblock copolymer hydro...

University of Massachusetts Amherst., Polymer Science & Engineering.

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PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure./
Author:	DeLong, Naomi Sanabria.
Description:	155 p.
Notes:	Adviser: Gregory N. Tew.
Contained By:	Dissertation Abstracts International69-12B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3336934
ISBN:	9780549915201

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.
DeLong, Naomi Sanabria.

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure. - 155 p.

Adviser: Gregory N. Tew.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2008.

Biodegradable hydrogels show great promise in the area of biomaterials and specifically for tissue engineering applications. While much work in the past has studied the various biochemical signals associated with cell growth, more recent work has highlighted the importance of the mechanical environment as a stimulus for growth. This dissertation focuses on associative network hydrogels formed for poly(lactide)-b-poly(ethylene oxide)-b-poly(lactide) [PLA-PEO-PLA] triblock copolymers and the factors that influence their mechanical properties, assembly, and structure. By controlling the stereospecificity of the PLA endblocks hydrogels with either amorphous or crystalline hydrophobic domains were formed as characterized using both X-ray and neutron scattering techniques. This change in structure directly impacted the mechanical properties of the hydrogels. Furthermore, complications in synthetic techniques introduced contaminants (asymmetric triblock copolymers or "effective" diblock copolymers) that impacted the assembly of the network to again impact the mechanical properties. Ultimately, the PLA-PEO-PLA triblock copolymer was chemically modified so that the self-assembled physical network served as a template for the covalently crosslinked network formed by photocrosslinking. The photocrosslinked hydrogels maintained their mechanical integrity in an aqueous environment; however, the measured mechanical properties were dependent on the assumed constitutive relationship.

ISBN: 9780549915201Subjects--Topical Terms:

1018428
Chemistry, Polymer.

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.
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020 $a 9780549915201
035 $a (UMI)AAI3336934
035 $a AAI3336934
040 $a UMI $c UMI
100 1 $a DeLong, Naomi Sanabria. $3 1018486
245 1 0 $a PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.
300 $a 155 p.
500 $a Adviser: Gregory N. Tew.
500 $a Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7537.
502 $a Thesis (Ph.D.)--University of Massachusetts Amherst, 2008.
520 $a Biodegradable hydrogels show great promise in the area of biomaterials and specifically for tissue engineering applications. While much work in the past has studied the various biochemical signals associated with cell growth, more recent work has highlighted the importance of the mechanical environment as a stimulus for growth. This dissertation focuses on associative network hydrogels formed for poly(lactide)-b-poly(ethylene oxide)-b-poly(lactide) [PLA-PEO-PLA] triblock copolymers and the factors that influence their mechanical properties, assembly, and structure. By controlling the stereospecificity of the PLA endblocks hydrogels with either amorphous or crystalline hydrophobic domains were formed as characterized using both X-ray and neutron scattering techniques. This change in structure directly impacted the mechanical properties of the hydrogels. Furthermore, complications in synthetic techniques introduced contaminants (asymmetric triblock copolymers or "effective" diblock copolymers) that impacted the assembly of the network to again impact the mechanical properties. Ultimately, the PLA-PEO-PLA triblock copolymer was chemically modified so that the self-assembled physical network served as a template for the covalently crosslinked network formed by photocrosslinking. The photocrosslinked hydrogels maintained their mechanical integrity in an aqueous environment; however, the measured mechanical properties were dependent on the assumed constitutive relationship.
590 $a School code: 0118.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0541
710 2 $a University of Massachusetts Amherst. $b Polymer Science & Engineering. $3 1018485
773 0 $t Dissertation Abstracts International $g 69-12B.
790 $a 0118
790 1 0 $a Bhatia, Surita R. $e committee member
790 1 0 $a Crosby, Alfred J. $e committee member
790 1 0 $a Tew, Gregory N., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3336934