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PLA-PEO-PLA triblock copolymer hydro...

University of Massachusetts Amherst., Polymer Science & Engineering.

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PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure./
作者:	DeLong, Naomi Sanabria.
面頁冊數:	155 p.
附註:	Adviser: Gregory N. Tew.
Contained By:	Dissertation Abstracts International69-12B.
標題:	Chemistry, Polymer. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3336934
ISBN:	9780549915201

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.
DeLong, Naomi Sanabria.

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure. - 155 p.

Adviser: Gregory N. Tew.

Thesis (Ph.D.)--University of Massachusetts Amherst, 2008.

Biodegradable hydrogels show great promise in the area of biomaterials and specifically for tissue engineering applications. While much work in the past has studied the various biochemical signals associated with cell growth, more recent work has highlighted the importance of the mechanical environment as a stimulus for growth. This dissertation focuses on associative network hydrogels formed for poly(lactide)-b-poly(ethylene oxide)-b-poly(lactide) [PLA-PEO-PLA] triblock copolymers and the factors that influence their mechanical properties, assembly, and structure. By controlling the stereospecificity of the PLA endblocks hydrogels with either amorphous or crystalline hydrophobic domains were formed as characterized using both X-ray and neutron scattering techniques. This change in structure directly impacted the mechanical properties of the hydrogels. Furthermore, complications in synthetic techniques introduced contaminants (asymmetric triblock copolymers or "effective" diblock copolymers) that impacted the assembly of the network to again impact the mechanical properties. Ultimately, the PLA-PEO-PLA triblock copolymer was chemically modified so that the self-assembled physical network served as a template for the covalently crosslinked network formed by photocrosslinking. The photocrosslinked hydrogels maintained their mechanical integrity in an aqueous environment; however, the measured mechanical properties were dependent on the assumed constitutive relationship.

ISBN: 9780549915201Subjects--Topical Terms:

1018428
Chemistry, Polymer.

PLA-PEO-PLA triblock copolymer hydrogels for soft tissue engineering: Properties, assembly, and structure.
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