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Amphiphilic block copolymers for bio...

University of Minnesota.

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Amphiphilic block copolymers for biomedical applications.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Amphiphilic block copolymers for biomedical applications./
Author:	Zupancich, John Andrew.
Description:	238 p.
Notes:	Advisers: Marc A. Hillmyer; Frank S. Bates.
Contained By:	Dissertation Abstracts International69-06B.
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3318040
ISBN:	9780549671213

Amphiphilic block copolymers for biomedical applications.
Zupancich, John Andrew.

Amphiphilic block copolymers for biomedical applications. - 238 p.

Advisers: Marc A. Hillmyer; Frank S. Bates.

Thesis (Ph.D.)--University of Minnesota, 2008.

Amphiphilic block copolymer self-assembly provides a versatile means to prepare nanoscale objects in solution. Control over aggregate shape is granted through manipulation of amphiphile composition and the synthesis of well-defined polymers offers the potential to produce micelles with geometries optimized for specific applications. Currently, polymer micelles are being investigated as vehicles for the delivery of therapeutics and attempts to increase efficacy has motivated efforts to incorporate bioactive ligands and stimuli-responsive character into these structures.

ISBN: 9780549671213Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Amphiphilic block copolymers for biomedical applications.
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020 $a 9780549671213
035 $a (UMI)AAI3318040
035 $a AAI3318040
040 $a UMI $c UMI
100 1 $a Zupancich, John Andrew. $3 1018427
245 1 0 $a Amphiphilic block copolymers for biomedical applications.
300 $a 238 p.
500 $a Advisers: Marc A. Hillmyer; Frank S. Bates.
500 $a Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: 3607.
502 $a Thesis (Ph.D.)--University of Minnesota, 2008.
520 $a Amphiphilic block copolymer self-assembly provides a versatile means to prepare nanoscale objects in solution. Control over aggregate shape is granted through manipulation of amphiphile composition and the synthesis of well-defined polymers offers the potential to produce micelles with geometries optimized for specific applications. Currently, polymer micelles are being investigated as vehicles for the delivery of therapeutics and attempts to increase efficacy has motivated efforts to incorporate bioactive ligands and stimuli-responsive character into these structures.
520 $a This thesis reports the synthesis and self-assembly of biocompatible, degradable polymeric amphiphiles. Spherical, cylindrical, and bilayered vesicle structures were generated spontaneously by the direct dispersion of poly(ethylene oxide)-b-poly(gamma-methyl-&egr;-caprolactone) block copolymers in water and solutions were characterized with cryogenic transmission electron microscopy (cryo-TEM). The dependence of micelle structure on diblock copolymer composition was examined through the systematic variation of the hydrophobic block molecular weight. A continuous evolution of morphology was observed with coexistence of aggregate structures occurring in windows of composition intermediate to that of pure spheres, cylinders and vesicles.
520 $a A number of heterobifunctional poly(ethylene oxide) polymers were synthesized for the preparation of ligand-functionalized amphiphilic diblock copolymers. The effect of ligand conjugation on block copolymer self-assembly and micelle morphology was also examined. An RGD-containing peptide sequence was efficiently conjugated to a set of well characterized poly(ethylene oxide)-b-poly(butadiene) copolymers. The reported aggregate morphologies of peptide-functionalized polymeric amphiphiles deviated from canonical structures and the micelle clustering, cylinder fragmentation, network formation, and multilayer vesicle generation documented with cryo-TEM was attributed to attractive interactions between ligands.
590 $a School code: 0130.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Materials Science. $3 1017759
690 $a 0495
690 $a 0794
710 2 $a University of Minnesota. $3 676231
773 0 $t Dissertation Abstracts International $g 69-06B.
790 $a 0130
790 1 0 $a Bates, Frank S., $e advisor
790 1 0 $a Hillmyer, Marc A., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3318040