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The modulation of the hepatic expres...

Long Island University, The Brooklyn Center.

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The modulation of the hepatic expression of the gene encoding the apolipoprotein II in response to estrogen and estrogen mimicking agents genistein, resveratrol, and catechin.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The modulation of the hepatic expression of the gene encoding the apolipoprotein II in response to estrogen and estrogen mimicking agents genistein, resveratrol, and catechin./
作者:	Arif, Ammar Bin.
面頁冊數:	116 p.
附註:	Adviser: Warren N. Ratna.
Contained By:	Masters Abstracts International46-05.
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1452431
ISBN:	9780549495802

The modulation of the hepatic expression of the gene encoding the apolipoprotein II in response to estrogen and estrogen mimicking agents genistein, resveratrol, and catechin.
Arif, Ammar Bin.

The modulation of the hepatic expression of the gene encoding the apolipoprotein II in response to estrogen and estrogen mimicking agents genistein, resveratrol, and catechin. - 116 p.

Adviser: Warren N. Ratna.

Thesis (M.S.)--Long Island University, The Brooklyn Center, 2008.

Apolipoprotein (apo)II is a yolk protein expressed in the liver in response to estrogen. It is a component of the very low-density lipoprotein particle (VLDL). The expression of apoII is modulated by estrogenic stimulation of transcription and by estrogen-mediated stabilization of its mRNA. The mechanism underlying hormonal regulation of mRNA stability until recently has remained unknown. The process of estrogenic regulation of apoII mRNA stability was first identified by Ratnasabapathy (1995), (Ratnasabapathy, R., 1995, Cell. Mol. Biol. Res., 41:583-594). The degradation of apoII mRNA is initiated by endonucleolytic cleavages at specific sites in the 3' untranslated region (3'UTR). The apoII mRNA is stabilized by a protein aptly termed the estrogen-regulated mRNA stabilizing factor (E-RmRNASF) that prevents its degradation. The gene encoding the E-RmRNASF itself is under estrogenic control. Estrogen mimicking xenobiotics (Ratnasabapathy et al., 1997, Bioch. Pharmacol., 53:1425-34) and certain phytochemicals (Ratna 2002, Life Sci. 71:865-77, Ratna and Simonelli 2002, Life Sci 70:1577-89, Ratna and Oyeamalu 2002, J. Steroid Biochem. Mol. Biol. 80:383-98, Ratna and Mehta 2004, XXII International Conference on Polyphenols, 47-48) also stabilize apoII mRNA. E-RmRNASF prevents the degradation of apoII mRNA by the endonuclease that initiates the decay process.

ISBN: 9780549495802Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

The modulation of the hepatic expression of the gene encoding the apolipoprotein II in response to estrogen and estrogen mimicking agents genistein, resveratrol, and catechin.
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245 1 4 $a The modulation of the hepatic expression of the gene encoding the apolipoprotein II in response to estrogen and estrogen mimicking agents genistein, resveratrol, and catechin.
300 $a 116 p.
500 $a Adviser: Warren N. Ratna.
500 $a Source: Masters Abstracts International, Volume: 46-05, page: 2661.
502 $a Thesis (M.S.)--Long Island University, The Brooklyn Center, 2008.
520 $a Apolipoprotein (apo)II is a yolk protein expressed in the liver in response to estrogen. It is a component of the very low-density lipoprotein particle (VLDL). The expression of apoII is modulated by estrogenic stimulation of transcription and by estrogen-mediated stabilization of its mRNA. The mechanism underlying hormonal regulation of mRNA stability until recently has remained unknown. The process of estrogenic regulation of apoII mRNA stability was first identified by Ratnasabapathy (1995), (Ratnasabapathy, R., 1995, Cell. Mol. Biol. Res., 41:583-594). The degradation of apoII mRNA is initiated by endonucleolytic cleavages at specific sites in the 3' untranslated region (3'UTR). The apoII mRNA is stabilized by a protein aptly termed the estrogen-regulated mRNA stabilizing factor (E-RmRNASF) that prevents its degradation. The gene encoding the E-RmRNASF itself is under estrogenic control. Estrogen mimicking xenobiotics (Ratnasabapathy et al., 1997, Bioch. Pharmacol., 53:1425-34) and certain phytochemicals (Ratna 2002, Life Sci. 71:865-77, Ratna and Simonelli 2002, Life Sci 70:1577-89, Ratna and Oyeamalu 2002, J. Steroid Biochem. Mol. Biol. 80:383-98, Ratna and Mehta 2004, XXII International Conference on Polyphenols, 47-48) also stabilize apoII mRNA. E-RmRNASF prevents the degradation of apoII mRNA by the endonuclease that initiates the decay process.
520 $a My thesis project involved the study of the effects of phytochemicals such as genistein, resveratrol, and catechin on the expression of apo II mRNA and its protein. These three phytochemicals are purported to have positive effects on health. Since it has already been shown that genistein and resveratrol induce the transcription and translation of the apo II stabilizing factor, it was assumed that apo II transcription and translation would also be stimulated. However, the result from western blot showed that the translation of apo II is upregulated only by estrogen and not by the estrogen mimicking agents. To prove that the estrogen mimicking agents do not upregulate apoII transcription, RNase protection assay was conducted. This assay gave similar results to the western blot.
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