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Regulation and function of a cluster...

Iowa State University., Veterinary Microbiology and Preventative Medicine.

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Regulation and function of a cluster of lipoproteins in Campylobacter jejuni.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Regulation and function of a cluster of lipoproteins in Campylobacter jejuni./
Author:	Fukuda, Mayumi.
Description:	90 p.
Notes:	Adviser: Qijing Zhang.
Contained By:	Masters Abstracts International46-01.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1446025
ISBN:	9780549140672

Regulation and function of a cluster of lipoproteins in Campylobacter jejuni.
Fukuda, Mayumi.

Regulation and function of a cluster of lipoproteins in Campylobacter jejuni. - 90 p.

Adviser: Qijing Zhang.

Thesis (M.S.)--Iowa State University, 2007.

Membrane-associated lipoproteins have important functions in bacterial pathogenesis and physiology. According to the available genomic sequences, C. jejuni possesses multiple lipoproteins, but the majority of them have not yet been functionally characterized. To better understand the pathogenic mechanisms of C. jejuni, in this work we characterized a three-gene operon (cj0089, cj0090, and cj0091) encoding a cluster of lipoproteins. It was shown that this lipoprotein-encoding operon is indirectly regulated by CmeR, a transcriptional regulator repressing the expression of the multidrug efflux pump CmeABC in C. jejuni. We determined that Cj0091 is an outer membrane associated protein, identified it as a new adhesin in C. jejuni, and demonstrated that this protein is involved in Campylobacter colonization in vivo. This study suggests that Cj0091 may be a promising candidate for the development of vaccines to reduce Campylobacter colonization in animal hosts.

ISBN: 9780549140672Subjects--Topical Terms:

1017734
Biology, Microbiology.

Regulation and function of a cluster of lipoproteins in Campylobacter jejuni.
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020 $a 9780549140672
035 $a (UMI)AAI1446025
035 $a AAI1446025
040 $a UMI $c UMI
100 1 $a Fukuda, Mayumi. $3 1017892
245 1 0 $a Regulation and function of a cluster of lipoproteins in Campylobacter jejuni.
300 $a 90 p.
500 $a Adviser: Qijing Zhang.
500 $a Source: Masters Abstracts International, Volume: 46-01, page: 0262.
502 $a Thesis (M.S.)--Iowa State University, 2007.
520 $a Membrane-associated lipoproteins have important functions in bacterial pathogenesis and physiology. According to the available genomic sequences, C. jejuni possesses multiple lipoproteins, but the majority of them have not yet been functionally characterized. To better understand the pathogenic mechanisms of C. jejuni, in this work we characterized a three-gene operon (cj0089, cj0090, and cj0091) encoding a cluster of lipoproteins. It was shown that this lipoprotein-encoding operon is indirectly regulated by CmeR, a transcriptional regulator repressing the expression of the multidrug efflux pump CmeABC in C. jejuni. We determined that Cj0091 is an outer membrane associated protein, identified it as a new adhesin in C. jejuni, and demonstrated that this protein is involved in Campylobacter colonization in vivo. This study suggests that Cj0091 may be a promising candidate for the development of vaccines to reduce Campylobacter colonization in animal hosts.
590 $a School code: 0097.
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0410
710 2 $a Iowa State University. $b Veterinary Microbiology and Preventative Medicine. $3 1017891
773 0 $t Masters Abstracts International $g 46-01.
790 $a 0097
790 1 0 $a Zhang, Qijing, $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1446025