東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Toxic metal complexation by 5-hydrox...

University of South Alabama.

FindBook

Google Book

Amazon

博客來

Toxic metal complexation by 5-hydroxy-2-hydroxymethylpyran-4-one and N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Toxic metal complexation by 5-hydroxy-2-hydroxymethylpyran-4-one and N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one./
作者:	Obiako, Anthony U.
面頁冊數:	90 p.
附註:	Adviser: Eugene A. Cioffi.
Contained By:	Masters Abstracts International46-01.
標題:	Environmental Sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1444824
ISBN:	9780549079408

Toxic metal complexation by 5-hydroxy-2-hydroxymethylpyran-4-one and N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one.
Obiako, Anthony U.

Toxic metal complexation by 5-hydroxy-2-hydroxymethylpyran-4-one and N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one. - 90 p.

Adviser: Eugene A. Cioffi.

Thesis (M.S.)--University of South Alabama, 2007.

The binding of 5-hydroxy-2-hydroxymethyl-4-pyrone (Kojic acid, KA) and 5-hydroxy-l-methyl-2hydroxymethylene-1H-pyridin-4-one (N-methyl kojic acid, N-KA) with environmentally relevant toxic metal ions (e.g Ag+, Al3+, As3+, Cd2+, Co 2+, Cr3+, Cu2+, Fe3+, Ga3+, Gd3+, Hg2+, In3+ , Pb2+) were characterized by isothermal titration calorimetry (ITC). The purpose of this study was two fold: (i) to investigate the thermodynamics of binding of the fungal metabolite, Kojic acid and its derivative, N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one to these environmentally relevant toxic metals and some other metals (In3+, Ga 3+ and Gd3+) that have applications in radiotherapy and imaging. These metals have been implicated in various disease conditions. (ii) Previous work has established the binding of Kojic acid and its derivatives to iron. We looked at the possibility of binding to these toxic metals. The underlying tenet is that such information will be invaluable for ligand design of the specific chelators for various toxic metals ions since thermodynamic data can be used to design and optimize drugs. From the data obtained, it can be noted that KA and N-KA formed complexes with all the metals titrated. The binding of all the metals to both substrates were enthalpically-driven.

ISBN: 9780549079408Subjects--Topical Terms:

676987
Environmental Sciences.

Toxic metal complexation by 5-hydroxy-2-hydroxymethylpyran-4-one and N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one.
LDR:02210nam 2200289 a 45 001 852132
005 20100629
008 100629s2007 ||||||||||||||||| ||eng d
020 $a 9780549079408
035 $a (UMI)AAI1444824
035 $a AAI1444824
040 $a UMI $c UMI
100 1 $a Obiako, Anthony U. $3 1017880
245 1 0 $a Toxic metal complexation by 5-hydroxy-2-hydroxymethylpyran-4-one and N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one.
300 $a 90 p.
500 $a Adviser: Eugene A. Cioffi.
500 $a Source: Masters Abstracts International, Volume: 46-01, page: 0359.
502 $a Thesis (M.S.)--University of South Alabama, 2007.
520 $a The binding of 5-hydroxy-2-hydroxymethyl-4-pyrone (Kojic acid, KA) and 5-hydroxy-l-methyl-2hydroxymethylene-1H-pyridin-4-one (N-methyl kojic acid, N-KA) with environmentally relevant toxic metal ions (e.g Ag+, Al3+, As3+, Cd2+, Co 2+, Cr3+, Cu2+, Fe3+, Ga3+, Gd3+, Hg2+, In3+ , Pb2+) were characterized by isothermal titration calorimetry (ITC). The purpose of this study was two fold: (i) to investigate the thermodynamics of binding of the fungal metabolite, Kojic acid and its derivative, N-methyl-3-hydroxy-6-hydroxymethylpyridin-4-one to these environmentally relevant toxic metals and some other metals (In3+, Ga 3+ and Gd3+) that have applications in radiotherapy and imaging. These metals have been implicated in various disease conditions. (ii) Previous work has established the binding of Kojic acid and its derivatives to iron. We looked at the possibility of binding to these toxic metals. The underlying tenet is that such information will be invaluable for ligand design of the specific chelators for various toxic metals ions since thermodynamic data can be used to design and optimize drugs. From the data obtained, it can be noted that KA and N-KA formed complexes with all the metals titrated. The binding of all the metals to both substrates were enthalpically-driven.
590 $a School code: 0491.
650 4 $a Environmental Sciences. $3 676987
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Toxicology. $3 1017752
690 $a 0383
690 $a 0573
690 $a 0768
710 2 $a University of South Alabama. $3 1017878
773 0 $t Masters Abstracts International $g 46-01.
790 $a 0491
790 1 0 $a Cioffi, Eugene A., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1444824