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Extra-pituitary functions for GnRH.

University of Wyoming.

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Extra-pituitary functions for GnRH.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Extra-pituitary functions for GnRH./
Author:	Albertson, Asher J.
Description:	89 p.
Notes:	Adviser: Donal C. Skinner.
Contained By:	Masters Abstracts International45-05.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1443264

Extra-pituitary functions for GnRH.
Albertson, Asher J.

Extra-pituitary functions for GnRH. - 89 p.

Adviser: Donal C. Skinner.

Thesis (M.S.)--University of Wyoming, 2007.

Gonadotropin Releasing Hormone (GnRH) is a hypothalamic decapeptide with a well known role as the primary regulatory of gonadal function. It exerts this regulation by controlling the release of the gonadotropins, Follicle Stimulating Hormone and Luteinizing Hormone from the anterior pituitary gland. While this role for GnRH is widely accepted, it is becoming apparent that GnRH may actually have a variety of vital roles in normal physiology. This has become evident from work implicating actions of GnRH in a variety of non-pituitary tissues. Most interesting of these tissues is the brain. We further elucidated potential extra-pituitary roles for GnRH within the brain by using immunohistochemistry to label the specific neural regions expressing the GnRH receptor. Additionally, we labeled pituitary gonadotrope cells for the GnRH receptor, something previously absent from the literature. Within the brain, the GnRH receptor was expressed in a variety of regions including the cerebral cortex, cerebellum, hippocampus, amygdala, olfactory system, preoptic region, lateral septum, and hypothalamus. It is clear that the GnRH receptor is widely distributed in a variety of neural regions leaving the potential that GnRH influences the activity of many neural pathways. Because of strong GnRH receptor immunoreactivity in neural regions vital to thermoregulation, we examined whether GnRH was capable of eliciting skin temperature change. First we designed a system in sheep through which peripheral skin temperature change could be reliably measured using lipopolysaccharide as a control inducer of transient temperature change. Next we performed large, IV, bolus injection of GnRH, however, no change in peripheral skin temperature was observed following such injections. While we were unable to induce peripheral temperature change in sheep using GnRH, further work must be done before the possibility that GnRH influences thermoregulation can be ruled out.Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Extra-pituitary functions for GnRH.
LDR:02748nam 2200265 a 45 001 852121
005 20100629
008 100629s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI1443264
035 $a AAI1443264
040 $a UMI $c UMI
100 1 $a Albertson, Asher J. $3 1017860
245 1 0 $a Extra-pituitary functions for GnRH.
300 $a 89 p.
500 $a Adviser: Donal C. Skinner.
500 $a Source: Masters Abstracts International, Volume: 45-05, page: 2368.
502 $a Thesis (M.S.)--University of Wyoming, 2007.
520 $a Gonadotropin Releasing Hormone (GnRH) is a hypothalamic decapeptide with a well known role as the primary regulatory of gonadal function. It exerts this regulation by controlling the release of the gonadotropins, Follicle Stimulating Hormone and Luteinizing Hormone from the anterior pituitary gland. While this role for GnRH is widely accepted, it is becoming apparent that GnRH may actually have a variety of vital roles in normal physiology. This has become evident from work implicating actions of GnRH in a variety of non-pituitary tissues. Most interesting of these tissues is the brain. We further elucidated potential extra-pituitary roles for GnRH within the brain by using immunohistochemistry to label the specific neural regions expressing the GnRH receptor. Additionally, we labeled pituitary gonadotrope cells for the GnRH receptor, something previously absent from the literature. Within the brain, the GnRH receptor was expressed in a variety of regions including the cerebral cortex, cerebellum, hippocampus, amygdala, olfactory system, preoptic region, lateral septum, and hypothalamus. It is clear that the GnRH receptor is widely distributed in a variety of neural regions leaving the potential that GnRH influences the activity of many neural pathways. Because of strong GnRH receptor immunoreactivity in neural regions vital to thermoregulation, we examined whether GnRH was capable of eliciting skin temperature change. First we designed a system in sheep through which peripheral skin temperature change could be reliably measured using lipopolysaccharide as a control inducer of transient temperature change. Next we performed large, IV, bolus injection of GnRH, however, no change in peripheral skin temperature was observed following such injections. While we were unable to induce peripheral temperature change in sheep using GnRH, further work must be done before the possibility that GnRH influences thermoregulation can be ruled out.
590 $a School code: 0264.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Neuroscience. $3 1017680
690 $a 0317
690 $a 0433
710 2 $a University of Wyoming. $3 1017859
773 0 $t Masters Abstracts International $g 45-05.
790 $a 0264
790 1 0 $a Skinner, Donal C., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1443264