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Interleukin 10 (IL-10) selectively i...

Florida Atlantic University.

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Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity./
Author:	Solomon, Evertz Stenson.
Description:	35 p.
Notes:	Adviser: Janet Blanks.
Contained By:	Masters Abstracts International45-05.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441990

Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
Solomon, Evertz Stenson.

Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity. - 35 p.

Adviser: Janet Blanks.

Thesis (M.S.)--Florida Atlantic University, 2007.

Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy.Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
LDR:01872nam 2200277 a 45 001 852111
005 20100629
008 100629s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI1441990
035 $a AAI1441990
040 $a UMI $c UMI
100 1 $a Solomon, Evertz Stenson. $3 1017838
245 1 0 $a Interleukin 10 (IL-10) selectively inhibits neovascularization in the murine model of retinopathy of prematurity.
300 $a 35 p.
500 $a Adviser: Janet Blanks.
500 $a Source: Masters Abstracts International, Volume: 45-05, page: 2371.
502 $a Thesis (M.S.)--Florida Atlantic University, 2007.
520 $a Ocular neovascularization (NV), the development of new blood vessels in the eye, occurs when excessive vascular endothelial growth factor (VEGF) is produced. Eventually NV may lead to photoreceptor loss and or blindness, as it does in age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and diabetic retinopathy.
520 $a We tested the hypothesis that the anti-inflammatory cytokine, interleukin-10 (IL-10); can reduce inflammation and block NV in the affected areas of the retina. The mouse ROP model was used for this study of NV. Seven day old neonates stayed in 75% oxygen for five days, then were given intraocular injection of IL-10 and NV was evaluated after seven days in room air. Controls were uninjected contralateral eyes. IL-10 strongly inhibited NV without affecting intra-retinal vessels. The selective inhibition of IL-10 on NV suggest a possible therapeutic use in infants with ROP, in diabetic retinopathy, and possibly, in AMD where inflammation is a risk factor.
590 $a School code: 0119.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0317
690 $a 0760
710 2 $a Florida Atlantic University. $3 1017837
773 0 $t Masters Abstracts International $g 45-05.
790 $a 0119
790 1 0 $a Blanks, Janet, $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441990