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The role of luxS in Escherichia coli...

University of Delaware.

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The role of luxS in Escherichia coli biofilm formation: A link between quorum sensing and central metabolism.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of luxS in Escherichia coli biofilm formation: A link between quorum sensing and central metabolism./
Author:	Thompson, Maren L.
Description:	88 p.
Notes:	Adviser: Diane S. Herson.
Contained By:	Masters Abstracts International45-03.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1440617

The role of luxS in Escherichia coli biofilm formation: A link between quorum sensing and central metabolism.
Thompson, Maren L.

The role of luxS in Escherichia coli biofilm formation: A link between quorum sensing and central metabolism. - 88 p.

Adviser: Diane S. Herson.

Thesis (M.S.)--University of Delaware, 2007.

The mechanism of Escherichia coli biofilm formation has been studied extensively, and is commonly used as a model for biofilm formation by other Gram negative bacteria. E. coli biofilms are frequently found on indwelling medical devices, and have been known to cause a number of infections including chronic urinary tract infections, chronic bacterial prostatitis, and pelvic inflammatory disease. The resistance of E. coli biofilms to antibiotics is a critical concern. Once a biofilm is established, the infection is almost impossible to treat. Since bacteria within a biofilm encounter relatively high cell concentrations, it is likely that quorum sensing, or bacterial cell-to-cell communication, plays an important role in biofilm formation and maturation. If we can better understand the role of quorum sensing in biofilm formation, it may become possible to develop a treatment that inhibits biofilm formation, thus preventing infection.Subjects--Topical Terms:

1017734
Biology, Microbiology.

The role of luxS in Escherichia coli biofilm formation: A link between quorum sensing and central metabolism.
LDR:02672nam 2200265 a 45 001 852104
005 20100629
008 100629s2007 ||||||||||||||||| ||eng d
035 $a (UMI)AAI1440617
035 $a AAI1440617
040 $a UMI $c UMI
100 1 $a Thompson, Maren L. $3 1017827
245 1 4 $a The role of luxS in Escherichia coli biofilm formation: A link between quorum sensing and central metabolism.
300 $a 88 p.
500 $a Adviser: Diane S. Herson.
500 $a Source: Masters Abstracts International, Volume: 45-03, page: 1380.
502 $a Thesis (M.S.)--University of Delaware, 2007.
520 $a The mechanism of Escherichia coli biofilm formation has been studied extensively, and is commonly used as a model for biofilm formation by other Gram negative bacteria. E. coli biofilms are frequently found on indwelling medical devices, and have been known to cause a number of infections including chronic urinary tract infections, chronic bacterial prostatitis, and pelvic inflammatory disease. The resistance of E. coli biofilms to antibiotics is a critical concern. Once a biofilm is established, the infection is almost impossible to treat. Since bacteria within a biofilm encounter relatively high cell concentrations, it is likely that quorum sensing, or bacterial cell-to-cell communication, plays an important role in biofilm formation and maturation. If we can better understand the role of quorum sensing in biofilm formation, it may become possible to develop a treatment that inhibits biofilm formation, thus preventing infection.
520 $a In the present study, the role of LuxS-based quorum sensing in E. coli biofilm formation was examined using a luxS-null strain. The LuxS-based quorum sensing system was found to play a significant role in biofilm formation, both through its role in autoinducer-2 (AI-2) production and its role in central metabolism. The DeltaluxS strain was unable to form a mature biofilm due to the down-regulation of the fliC gene, which encodes the flagellar structural protein. The attached E. coli DeltaluxS cells produced an excess of extracellular matrix (ECM), most likely due to the up-regulation of the metR gene, which encodes a transcriptional regulator of several genes involved in methionine synthesis. The DeltaluxS strain was also shown to produce less S-Adenosylmethionine (SAM) than its parent strain, which resulted in a slowed growth rate and a cell division defect.
590 $a School code: 0060.
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0410
710 2 $a University of Delaware. $3 1017826
773 0 $t Masters Abstracts International $g 45-03.
790 $a 0060
790 1 0 $a Herson, Diane S., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1440617