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Toxicity and bioaccumulation of the ...

St. John's University (New York).

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Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of maternal and newborn Long-Evans rats.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of maternal and newborn Long-Evans rats./
作者:	Scharf, Brian.
面頁冊數:	54 p.
附註:	Adviser: Louis Trombetta.
Contained By:	Dissertation Abstracts International68-12B.
標題:	Health Sciences, Toxicology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3293281
ISBN:	9780549372165

Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of maternal and newborn Long-Evans rats.
Scharf, Brian.

Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of maternal and newborn Long-Evans rats. - 54 p.

Adviser: Louis Trombetta.

Thesis (Ph.D.)--St. John's University (New York), 2008.

Copper dimethyldithiocarbamate (CDDC) has been recently introduced as an alternative to chromated copper arsenate (CCA) preserved wood. The potential effects on human health and the environment with CDDC-treated wood have not been examined. This study investigated the toxicity and accumulation of copper in the hippocampus of maternal and newborn Long-Evans rats, and in maternal livers and kidneys following a subacute exposure to CDDC. Pregnant rats (220-270 g) were treated daily with 0, 25, 50, or 75 mg/kg CDDC by oral gavage starting from day 6 of gestation and continuing to parturition. Following parturition, maternal and newborn rats were euthanized. Brain, liver, and renal tissues were removed, processed, and stored for analysis. Electron microscopy revealed demyelination and by-products of peroxidative damage in treated maternal hippocampi. Treated newborn hippocampi exhibited numerous degenerating mitochondria, membrane bound inclusion bodies, and vacuoles containing degraded structures. Western blot analysis revealed an induction of stress proteins HO-1 and Hsp70, and the formation of 4-hydroxy-2-nonenal (4HNE) adducts. Overt destruction of liver architecture and renal tissue was observed. Graphite furnace atomic absorption spectrophotometry demonstrated a significant increase in copper concentration in the tissues of treated animals as compared to controls. CDDC was shown to be toxic to the brains, livers, and kidneys at all doses used, and this toxicity is attributable to copper-induced lipid peroxidation.

ISBN: 9780549372165Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

Toxicity and bioaccumulation of the wood preservative copper dimethyldithiocarbamate in tissues of maternal and newborn Long-Evans rats.
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520 $a Copper dimethyldithiocarbamate (CDDC) has been recently introduced as an alternative to chromated copper arsenate (CCA) preserved wood. The potential effects on human health and the environment with CDDC-treated wood have not been examined. This study investigated the toxicity and accumulation of copper in the hippocampus of maternal and newborn Long-Evans rats, and in maternal livers and kidneys following a subacute exposure to CDDC. Pregnant rats (220-270 g) were treated daily with 0, 25, 50, or 75 mg/kg CDDC by oral gavage starting from day 6 of gestation and continuing to parturition. Following parturition, maternal and newborn rats were euthanized. Brain, liver, and renal tissues were removed, processed, and stored for analysis. Electron microscopy revealed demyelination and by-products of peroxidative damage in treated maternal hippocampi. Treated newborn hippocampi exhibited numerous degenerating mitochondria, membrane bound inclusion bodies, and vacuoles containing degraded structures. Western blot analysis revealed an induction of stress proteins HO-1 and Hsp70, and the formation of 4-hydroxy-2-nonenal (4HNE) adducts. Overt destruction of liver architecture and renal tissue was observed. Graphite furnace atomic absorption spectrophotometry demonstrated a significant increase in copper concentration in the tissues of treated animals as compared to controls. CDDC was shown to be toxic to the brains, livers, and kidneys at all doses used, and this toxicity is attributable to copper-induced lipid peroxidation.
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