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Thermoplastic Elastomer Research and...

McClain, Andrew T.

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Thermoplastic Elastomer Research and Development for Healthcare Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Thermoplastic Elastomer Research and Development for Healthcare Applications./
Author:	McClain, Andrew T.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	215 p.
Notes:	Source: Dissertations Abstracts International, Volume: 86-02, Section: B.
Contained By:	Dissertations Abstracts International86-02B.
Subject:	Nanotechnology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31575615
ISBN:	9798383584644

Thermoplastic Elastomer Research and Development for Healthcare Applications.
McClain, Andrew T.

Thermoplastic Elastomer Research and Development for Healthcare Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 215 p.

Source: Dissertations Abstracts International, Volume: 86-02, Section: B.

Thesis (Ph.D.)--The University of Akron, 2024.

Thermoplastic elastomers (TPE) are a set of materials with characteristics of elastomers and thermoplastics. There is an increasing demand for polymers to be processed into three dimensional porous constructs for tissue engineering. Aliphatic polyester-based, poly(butylene succinate-co-dilinoleic succinate) (PBS-DLS) and polyisobutylene-based, poly(alloocimene-b-isobutylene-b-alloocimene) thermoplastic elastomer copolymers and their development will be presented for end use as biomaterial-based therapies in this dissertation. Electrospun fibrous scaffolds are favored for tissue engineering for their micro-structured networks creating a high surface area to volume ratio and this high interconnected porosity. These properties help mimic natural tissue structure for better tissue integration and diffusion through the network. Applying thermoplastic elastomers as scaffolds offers materials whose material properties can be tailored for specific applications. This dissertation presents work to advance biodegradable aliphatic copolymers for tissue scaffolds, and polyisobutylene copolymers for drug delivery applications. Cardiac soft tissue regenerations strategies employ biodegradative copolymers for cell delivery. Completely bio-based and biodegradable PBS-DLS copolymers have shown great potential for coiled 3D scaffolds for cardiac applications. This dissertation presents the kinetics of a step enzymatic polycondensation of PBS-DLS copolymers with varying feed ratios. 1H NMR and SEC results found that hydrophobic soft segment DLS was incorporated into the hard segment PBS within the first 3 hours. After which, the pressure was increased during second stage and complete DLS incorporation and high Mn oligomers occurred between 24 and 48 hours. MALDI-ToF analysis showed that the lower molecular weight fractions cyclic formation of long PBS sequences are favored during early stages of reactions. Poly(styrene-b-isobutylene-b-styrene) is currently used as the coating on the Taxus coronary drug eluting stent. Sequential generations of polyisobutylne-based materials have been made and studied for drug release applications. Specific aim two of this dissertation presents the development of poly(ρ-methylstyrene-b-isobutylene-b-ρ-methylstyrene) (arb_SIBS) and poly(alloocimene-b-isobutylene-b-alloocimene) (AIBA) for drug delivery. Analysis found materials to be non-toxic and able to release anti-inflammatory drugs. AIBA was loaded with ZAF and implanted in vivo. Analysis found this combination to illicit less inflammation than silicone rubber and is as effective as orally administrated zafirlukast to mitigate fibrous capsule development for up to 90 days in vivo.

ISBN: 9798383584644Subjects--Topical Terms:

526235
Nanotechnology.
Subjects--Index Terms:

Thermoplastic elastomers

Thermoplastic Elastomer Research and Development for Healthcare Applications.
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520 $a Thermoplastic elastomers (TPE) are a set of materials with characteristics of elastomers and thermoplastics. There is an increasing demand for polymers to be processed into three dimensional porous constructs for tissue engineering. Aliphatic polyester-based, poly(butylene succinate-co-dilinoleic succinate) (PBS-DLS) and polyisobutylene-based, poly(alloocimene-b-isobutylene-b-alloocimene) thermoplastic elastomer copolymers and their development will be presented for end use as biomaterial-based therapies in this dissertation. Electrospun fibrous scaffolds are favored for tissue engineering for their micro-structured networks creating a high surface area to volume ratio and this high interconnected porosity. These properties help mimic natural tissue structure for better tissue integration and diffusion through the network. Applying thermoplastic elastomers as scaffolds offers materials whose material properties can be tailored for specific applications. This dissertation presents work to advance biodegradable aliphatic copolymers for tissue scaffolds, and polyisobutylene copolymers for drug delivery applications. Cardiac soft tissue regenerations strategies employ biodegradative copolymers for cell delivery. Completely bio-based and biodegradable PBS-DLS copolymers have shown great potential for coiled 3D scaffolds for cardiac applications. This dissertation presents the kinetics of a step enzymatic polycondensation of PBS-DLS copolymers with varying feed ratios. 1H NMR and SEC results found that hydrophobic soft segment DLS was incorporated into the hard segment PBS within the first 3 hours. After which, the pressure was increased during second stage and complete DLS incorporation and high Mn oligomers occurred between 24 and 48 hours. MALDI-ToF analysis showed that the lower molecular weight fractions cyclic formation of long PBS sequences are favored during early stages of reactions. Poly(styrene-b-isobutylene-b-styrene) is currently used as the coating on the Taxus coronary drug eluting stent. Sequential generations of polyisobutylne-based materials have been made and studied for drug release applications. Specific aim two of this dissertation presents the development of poly(ρ-methylstyrene-b-isobutylene-b-ρ-methylstyrene) (arb_SIBS) and poly(alloocimene-b-isobutylene-b-alloocimene) (AIBA) for drug delivery. Analysis found materials to be non-toxic and able to release anti-inflammatory drugs. AIBA was loaded with ZAF and implanted in vivo. Analysis found this combination to illicit less inflammation than silicone rubber and is as effective as orally administrated zafirlukast to mitigate fibrous capsule development for up to 90 days in vivo.
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