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Precision-Porous Biomaterials for Sk...

Wyatt, Meghan.

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Precision-Porous Biomaterials for Skin Healing.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Precision-Porous Biomaterials for Skin Healing./
Author:	Wyatt, Meghan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	47 p.
Notes:	Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
Contained By:	Dissertations Abstracts International86-01B.
Subject:	Biomedical engineering. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31328474
ISBN:	9798383219973

Precision-Porous Biomaterials for Skin Healing.
Wyatt, Meghan.

Precision-Porous Biomaterials for Skin Healing. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 47 p.

Source: Dissertations Abstracts International, Volume: 86-01, Section: B.

Thesis (Ph.D.)--University of Washington, 2024.

Current percutaneous devices often fail due to poor implant integration associated with the foreign body response (FBR). It is hypothesized that 40µm precision-porous biomaterials can inhibit the FBR to percutaneous devices. We investigated both synthetic and natural materials as potential candidates for precision-porous percutaneous device materials. Precision-porous polyurethane (PU) models of a catheter cuff were studied in vivo in a pig model. These PU constructs demonstrated a reduced FBR and better skin healing outcomes than solid implants. Subcutaneous implant models of precision-porous PU further demonstrated the ability of these materials to mitigate the FBR and improve angiogenesis. Analysis of RNA expression in subcutaneous models provided potential insights on the mechanism behind this pro-healing response. In the final component of this work, we investigated biodegradable biomaterials for use in percutaneous healing applications. Non-toxic, biodegradable PUs were developed.

ISBN: 9798383219973Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Biodegradable biomaterials

Precision-Porous Biomaterials for Skin Healing.
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500 $a Source: Dissertations Abstracts International, Volume: 86-01, Section: B.
500 $a Advisor: Ratner, Buddy D.
502 $a Thesis (Ph.D.)--University of Washington, 2024.
520 $a Current percutaneous devices often fail due to poor implant integration associated with the foreign body response (FBR). It is hypothesized that 40µm precision-porous biomaterials can inhibit the FBR to percutaneous devices. We investigated both synthetic and natural materials as potential candidates for precision-porous percutaneous device materials. Precision-porous polyurethane (PU) models of a catheter cuff were studied in vivo in a pig model. These PU constructs demonstrated a reduced FBR and better skin healing outcomes than solid implants. Subcutaneous implant models of precision-porous PU further demonstrated the ability of these materials to mitigate the FBR and improve angiogenesis. Analysis of RNA expression in subcutaneous models provided potential insights on the mechanism behind this pro-healing response. In the final component of this work, we investigated biodegradable biomaterials for use in percutaneous healing applications. Non-toxic, biodegradable PUs were developed.
590 $a School code: 0250.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Dermatology. $3 829009
650 4 $a Medical imaging. $3 3172799
650 4 $a Immunology. $3 611031
653 $a Biodegradable biomaterials
653 $a Precision-porous polyurethane
653 $a Skin healing
653 $a Foreign body response
653 $a Synthetic materials
690 $a 0541
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690 $a 0982
690 $a 0757
710 2 $a University of Washington. $b Bioengineering. $3 2094898
773 0 $t Dissertations Abstracts International $g 86-01B.
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856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31328474