東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Morphogenetic Engineering of Synthet...

Zhu, Qinyu.

Linked to FindBook

Google Book

Amazon

博客來

Morphogenetic Engineering of Synthetic Protocell Systems.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Morphogenetic Engineering of Synthetic Protocell Systems./
Author:	Zhu, Qinyu.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	207 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
Contained By:	Dissertations Abstracts International85-04B.
Subject:	Surfactants. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30614054
ISBN:	9798380481243

Morphogenetic Engineering of Synthetic Protocell Systems.
Zhu, Qinyu.

Morphogenetic Engineering of Synthetic Protocell Systems. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 207 p.

Source: Dissertations Abstracts International, Volume: 85-04, Section: B.

Thesis (Ph.D.)--Brigham Young University, 2023.

Observing and studying how life forms behave, i.e., their movement, adaptability, and so on, have enabled human beings to develop new technologies or optimize existing ones. One of the more noticeable phenomena in Nature is morphogenesis. Morphogenetic processes exist in different stages of biological development, from cellular division to tissue and organ formation. It is easy to observe shape development during morphogenesis due to emerging imaging techniques. However, it is hard to understand this process due to its complex organization, and the morphogenetic responses can be induced by a variety of chemicals or mechanical stresses and are subject to the stochastic fluctuation of the environment, making it even more difficult to acquire a fundamental understanding.It is natural to think of mimicking the complex biological process using simplified synthetic approaches. Endowing synthetic protocells with the ability to control their shape and motion autonomously would enable them to perform more like a biological system, but with less complexity. Creating synthetic morphogenesis would potentially further our understanding in biological morphogenetic processes. Moreover, we can borrow some of the morphogenetic functions in engineered materials to achieve a variety of applications, including artificial tissues, self-healing materials, controlled drug delivery, manipulation of soft robots, among others.In this dissertation, we used a synthetic cellular system controlled by a reaction regulated network that imitates the genetic control as a minimal model to understand the potential mechanisms of morphogenesis. Different simulation methods were used depending on the length scales of interest in each problem. We studied the following aspects of the minimal model system: (a) catalytic reaction induced local morphological control of amphiphilic diblock copolymer vesicles; (b) non-equilibrium control over the self-assembled structures of amphiphilic surfactants; and (c) diffusiophoretic/self-diffusiophoretic motion of colloidal particles in response to the concentration gradient field. The results obtained in this thesis work will provide a valuable road-map to guide future experiments.

ISBN: 9798380481243Subjects--Topical Terms:

3560257
Surfactants.

Morphogenetic Engineering of Synthetic Protocell Systems.
LDR:03228nmm a2200337 4500 001 2403596
005 20241118135842.5
006 m o d
007 cr#unu||||||||
008 251215s2023 ||||||||||||||||| ||eng d
020 $a 9798380481243
035 $a (MiAaPQ)AAI30614054
035 $a (MiAaPQ)BrighamYoung10980
035 $a AAI30614054
040 $a MiAaPQ $c MiAaPQ
100 1 $a Zhu, Qinyu. $3 3773868
245 1 0 $a Morphogenetic Engineering of Synthetic Protocell Systems.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 207 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-04, Section: B.
500 $a Advisor: Tree, Douglas R.
502 $a Thesis (Ph.D.)--Brigham Young University, 2023.
520 $a Observing and studying how life forms behave, i.e., their movement, adaptability, and so on, have enabled human beings to develop new technologies or optimize existing ones. One of the more noticeable phenomena in Nature is morphogenesis. Morphogenetic processes exist in different stages of biological development, from cellular division to tissue and organ formation. It is easy to observe shape development during morphogenesis due to emerging imaging techniques. However, it is hard to understand this process due to its complex organization, and the morphogenetic responses can be induced by a variety of chemicals or mechanical stresses and are subject to the stochastic fluctuation of the environment, making it even more difficult to acquire a fundamental understanding.It is natural to think of mimicking the complex biological process using simplified synthetic approaches. Endowing synthetic protocells with the ability to control their shape and motion autonomously would enable them to perform more like a biological system, but with less complexity. Creating synthetic morphogenesis would potentially further our understanding in biological morphogenetic processes. Moreover, we can borrow some of the morphogenetic functions in engineered materials to achieve a variety of applications, including artificial tissues, self-healing materials, controlled drug delivery, manipulation of soft robots, among others.In this dissertation, we used a synthetic cellular system controlled by a reaction regulated network that imitates the genetic control as a minimal model to understand the potential mechanisms of morphogenesis. Different simulation methods were used depending on the length scales of interest in each problem. We studied the following aspects of the minimal model system: (a) catalytic reaction induced local morphological control of amphiphilic diblock copolymer vesicles; (b) non-equilibrium control over the self-assembled structures of amphiphilic surfactants; and (c) diffusiophoretic/self-diffusiophoretic motion of colloidal particles in response to the concentration gradient field. The results obtained in this thesis work will provide a valuable road-map to guide future experiments.
590 $a School code: 0022.
650 4 $a Surfactants. $3 3560257
650 4 $a Polymers. $3 535398
650 4 $a Behavior. $3 532476
650 4 $a Solvents. $3 620946
650 4 $a Chemical reactions. $3 519248
650 4 $a Microscopy. $3 540544
650 4 $a Computer simulation. $3 525602
650 4 $a Kinetics. $3 717752
650 4 $a Energy. $3 876794
650 4 $a Lipids. $3 558980
650 4 $a Enzymes. $3 520899
650 4 $a Morphogenesis. $3 810791
650 4 $a Visualization. $3 586179
650 4 $a Developmental biology. $3 592588
650 4 $a Polymer chemistry. $3 3173488
690 $a 0791
690 $a 0758
690 $a 0495
710 2 $a Brigham Young University. $3 1017451
773 0 $t Dissertations Abstracts International $g 85-04B.
790 $a 0022
791 $a Ph.D.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30614054