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One bite at a time: Exploring the im...

Moerings, Bart G. J.

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One bite at a time: Exploring the immune-enhancing potential of dietary fiber for human health.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	One bite at a time: Exploring the immune-enhancing potential of dietary fiber for human health./
作者:	Moerings, Bart G. J.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
面頁冊數:	243 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
標題:	Infections. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31472686
ISBN:	9798382829319

One bite at a time: Exploring the immune-enhancing potential of dietary fiber for human health.
Moerings, Bart G. J.

One bite at a time: Exploring the immune-enhancing potential of dietary fiber for human health. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 243 p.

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Wageningen University and Research, 2024.

Dietary fibers have been recognized for their impact on the gut microbiota and contribution to the development and supporting the immune system. These effects hold particular promise for individuals with compromised immune systems and the elderly. Unraveling the specific mechanisms through which dietary fibers enhance immunity opens avenues for developing novel food products with immune-boosting attributes. Here, we focused on two classes of commonly consumed immune-active dietary fibers; 1) β-glucans, a class of dietary fibers consisting of glucose subunits that belong to the non-digestible polysaccharide subclass hemicellulose, and 2) arabinoxylans, consisting mainly of arabinose and xylose subunits and a major component of dietary fiber found in cereals, such as oat, wheat, corn, rye, and rice bran. Activation of the innate immune system holds the promise of improving responses to subsequent stimuli, a phenomenon referred to as "trained innate immunity". This concept originates from the observation that, following a primary infection characterized by epigenetic remodeling and metabolic pathway rewiring, there is an enhanced innate immune response to both secondary and unrelated infections or stimuli. When the initial trigger remains accessible to cells over time the mechanistical processes might be identical, one could consider this "priming". While research demonstrates β-glucans' direct immune stimulation and potential to induce trained immunity, most evidence relies on invasive systemic administration. Limited data exist regarding the induction of trained immunity by orally ingested β-glucans and arabinoxylans. The aim of this thesis was to investigate whether oral intake of these dietary fibers can also induce trained immunity.

ISBN: 9798382829319Subjects--Topical Terms:

1621997
Infections.

One bite at a time: Exploring the immune-enhancing potential of dietary fiber for human health.
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