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Regulatory Roles of Adipocyte Glucoc...

Amatya, Shripa.

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Regulatory Roles of Adipocyte Glucocorticoid Receptor Signaling in Adipose Tissue.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulatory Roles of Adipocyte Glucocorticoid Receptor Signaling in Adipose Tissue./
Author:	Amatya, Shripa.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	198 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-06, Section: B.
Contained By:	Dissertations Abstracts International85-06B.
Subject:	Physiology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30813729
ISBN:	9798380945189

Regulatory Roles of Adipocyte Glucocorticoid Receptor Signaling in Adipose Tissue.
Amatya, Shripa.

Regulatory Roles of Adipocyte Glucocorticoid Receptor Signaling in Adipose Tissue. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 198 p.

Source: Dissertations Abstracts International, Volume: 85-06, Section: B.

Thesis (Ph.D.)--Louisiana State University Health Sciences Center - Shreveport, 2023.

Glucocorticoids acting via the glucocorticoid receptors (GR) are known to be key regulators of metabolism and stress response. However, uncontrolled, or excess GR signaling adversely can inflame adipose tissue to impact function of systemic endocrine, immune, and metabolic systems. Adipose tissue inflammation promotes systemic metabolic dysfunctions; however, the molecular mechanisms underlying the role of adipocyte GR in the regulation of genes associated with adipose tissue inflammation remain poorly understood. We performed in vivo studies using adipocyte-specific GR knockout mice (Adipo GRKO) in conjunction with in vitro studies to understand the contribution of adipocyte GR in regulating adipose tissue immune homeostasis. To examine the effect of systemic stress signaling on immune regulatory gene expression in adipose tissue, we performed studies where mice underwent acute psychogenic stress. We used both male and female mice to observe potential sex differences in adipocyte GR regulation of adipose tissue functions. Our findings showed that adipocyte specific GR signaling regulated adipokines at both mRNA and plasma levels, and immune regulatory (Coch, Pdcd1, Cemip, Cxcr2, Tnfa, Il6, and Il12a) mRNA gene expression, which affected myeloid immune cell presence in white adipose tissue. We found that in adipocytes, GR directly downregulated Cxcr2 whereas in non-adipocytes or stromal cells, adipocyte GR indirectly affected Pdcd1, Cemip and Il6 gene expression. Our findings suggest that adipocyte GR signaling suppresses inflammatory signals, maintaining immune homeostasis. We also found sex-specific differences in GR signaling in adipose tissue in response to stress. Elucidating physiological roles of adipocyte GR in maintaining endocrine, immune and metabolic homeostasis in adipose tissue will help explain pathologies associated with adipose tissue dysfunction.

ISBN: 9798380945189Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Acute stress

Regulatory Roles of Adipocyte Glucocorticoid Receptor Signaling in Adipose Tissue.
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