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Cellular Plasticity Within the Anter...

Lim, Juchan.

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Cellular Plasticity Within the Anterior Pituitary.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Cellular Plasticity Within the Anterior Pituitary./
作者:	Lim, Juchan.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	196 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-03, Section: B.
Contained By:	Dissertations Abstracts International85-03B.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30631756
ISBN:	9798380369770

Cellular Plasticity Within the Anterior Pituitary.
Lim, Juchan.

Cellular Plasticity Within the Anterior Pituitary. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 196 p.

Source: Dissertations Abstracts International, Volume: 85-03, Section: B.

Thesis (Ph.D.)--University of Arkansas for Medical Sciences, 2023.

High cellular plasticity within the adult anterior pituitary (AP) is critical for hormone homeostasis in response to physiological demands that are required for essential body functions such as growth, metabolism, reproduction, lactation, and stress response. Early findings suggest that transdifferentiation may potentially be involved in pituitary cell remodeling. My dissertation study focuses on adult anterior pituitary cell plasticity in two different physiological conditions as well as its underlying signaling pathways and post-transcriptional regulation. My hypothesis is that somatotropes, the most abundant cell among all AP hormone producing cell types, possess a transdifferentiation capacity with high plasticity that are potentially fine-tuned by post-transcriptional regulators such as Musashi during pituitary cell remodeling in response to altered physiological demands. To test this hypothesis, I employed RIP-Seq to identify 1184 pituitary-specific Musashi target mRNAs and validated MSI1- mediated translational repression of the gonadotrope-specific Fshb mRNA. Next, I verified somatotrope to lactotrope trandifferentiaiton and relevant signaling pathways involved in autophagy and unfolded protein reponses in GH3 cells and found 972 genes potentially post-transcriptionally regulated by both Musashi and other post-transcriptional regulators. Lastly, I confirmed somatotrope plasticity towards a thyrotrope cell fate and activated signaling pathways involved in synaptic plasticity, protein secretion and cell-cell signaling between pituitary hormone producing cells and, potentially, with pituitary stem cells and/or immune cells during hypothyroidism. I propose a significant contribution of somatotrope plasticity in response to two physiological demands and a significant contribution of posttranscriptional regulation.

ISBN: 9798380369770Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Anterior pituitary

Cellular Plasticity Within the Anterior Pituitary.
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