東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Investigating Smooth Muscle Myosin D...

Bennett, Margaret.

Linked to FindBook

Google Book

Amazon

博客來

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology./
Author:	Bennett, Margaret.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	103 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
Subject:	Cellular biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30570656
ISBN:	9798379944001

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
Bennett, Margaret.

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 103 p.

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--Loyola University Chicago, 2023.

Vascular smooth muscle cells (SMCs) line blood vessels throughout the body, where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. These mechanical and contractile functions are powered by the actin and smooth muscle myosin 2 cytoskeleton. To function, smooth muscle myosin transitions between an inactive monomeric state and an active filamentous state, which can then perform work on actin. Understanding the regulation of smooth muscle myosin activation at the molecular and cellular level is foundational for understanding tissue-level smooth muscle function and dysfunction in disease states. Indeed, mutations in smooth muscle myosin and dysregulation of actomyosin contractility are known drivers of smooth muscle pathologies, such as aortic aneurysms. The overarching goal of this work is to explore filament assembly and dynamics of smooth muscle myosin under normal physiological conditions, and look into how these may be changed in novel and pathology associated mutations.

ISBN: 9798379944001Subjects--Topical Terms:

3172791
Cellular biology.
Subjects--Index Terms:

Vascular smooth muscle cells

Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
LDR:02251nmm a2200385 4500 001 2401097
005 20241015112524.5
006 m o d
007 cr#unu||||||||
008 251215s2023 ||||||||||||||||| ||eng d
020 $a 9798379944001
035 $a (MiAaPQ)AAI30570656
035 $a AAI30570656
035 $a 2401097
040 $a MiAaPQ $c MiAaPQ
100 1 $a Bennett, Margaret. $3 3771160
245 1 0 $a Investigating Smooth Muscle Myosin Dynamics and Assembly in Physiology and Pathology.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 103 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
500 $a Advisor: Beach, Jordan.
502 $a Thesis (Ph.D.)--Loyola University Chicago, 2023.
520 $a Vascular smooth muscle cells (SMCs) line blood vessels throughout the body, where they dynamically alter vessel diameter to regulate blood pressure, provide structural integrity, and absorb shock on a beat-to-beat timescale. These mechanical and contractile functions are powered by the actin and smooth muscle myosin 2 cytoskeleton. To function, smooth muscle myosin transitions between an inactive monomeric state and an active filamentous state, which can then perform work on actin. Understanding the regulation of smooth muscle myosin activation at the molecular and cellular level is foundational for understanding tissue-level smooth muscle function and dysfunction in disease states. Indeed, mutations in smooth muscle myosin and dysregulation of actomyosin contractility are known drivers of smooth muscle pathologies, such as aortic aneurysms. The overarching goal of this work is to explore filament assembly and dynamics of smooth muscle myosin under normal physiological conditions, and look into how these may be changed in novel and pathology associated mutations.
590 $a School code: 0112.
650 4 $a Cellular biology. $3 3172791
650 4 $a Physiology. $3 518431
650 4 $a Pathology. $3 643180
653 $a Vascular smooth muscle cells
653 $a Aortic aneurysms
653 $a Pathology associated mutations
653 $a Actomyosin
690 $a 0379
690 $a 0571
690 $a 0719
710 2 $a Loyola University Chicago. $b Biology. $3 3182901
773 0 $t Dissertations Abstracts International $g 85-01B.
790 $a 0112
791 $a Ph.D.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30570656