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Growth Factor Regulation of Neurobla...

Park, Jenna.

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Growth Factor Regulation of Neuroblastoma Migration and Invasion.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Growth Factor Regulation of Neuroblastoma Migration and Invasion./
Author:	Park, Jenna.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
Description:	79 p.
Notes:	Source: Masters Abstracts International, Volume: 85-05.
Contained By:	Masters Abstracts International85-05.
Subject:	Biophysics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30530800
ISBN:	9798380832816

Growth Factor Regulation of Neuroblastoma Migration and Invasion.
Park, Jenna.

Growth Factor Regulation of Neuroblastoma Migration and Invasion. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 79 p.

Source: Masters Abstracts International, Volume: 85-05.

Thesis (M.Sc.)--University of Toronto (Canada), 2023.

Neuroblastoma (NB) is the most common extracranial pediatric cancer with a five-year survival rate of less than 50%. It arises from neural crest precursors in tissues such as the adrenal gland. Metastatic NB is often fatal with common sites including bone, bone marrow and brain. Our laboratory previously developed a mouse model of NB to study metastasis to the bone and the brain, isolated tumor cells from these metastatic sites and identified genes regulating their metastatic behavior. Since neural crest-derived cells often use receptor tyrosine kinases (RTKs) and their ligands to proliferate and migrate, I hypothesized that NB cells also use these proteins to metastasize. To address this, I performed mass spectroscopy analysis of NB cell surface proteins and scRNA-seq to identify RTKs and their ligands enriched in hypermetastatic NB cells as compared to less metastatic parental cells. I identified four RTKs, PDGFRA, PDGFRB, EGFR, and FGFR1 and found that the PDGFRB ligand PDGFBB mediated the migration and invasion of the hypermetastatic cells without markedly affecting the parental cells. These findings suggest that NB cells use PDGF to mediate part of the metastatic process.

ISBN: 9798380832816Subjects--Topical Terms:

518360
Biophysics.
Subjects--Index Terms:

Cancer

Growth Factor Regulation of Neuroblastoma Migration and Invasion.
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500 $a Source: Masters Abstracts International, Volume: 85-05.
500 $a Advisor: Irwin, Meredith.
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520 $a Neuroblastoma (NB) is the most common extracranial pediatric cancer with a five-year survival rate of less than 50%. It arises from neural crest precursors in tissues such as the adrenal gland. Metastatic NB is often fatal with common sites including bone, bone marrow and brain. Our laboratory previously developed a mouse model of NB to study metastasis to the bone and the brain, isolated tumor cells from these metastatic sites and identified genes regulating their metastatic behavior. Since neural crest-derived cells often use receptor tyrosine kinases (RTKs) and their ligands to proliferate and migrate, I hypothesized that NB cells also use these proteins to metastasize. To address this, I performed mass spectroscopy analysis of NB cell surface proteins and scRNA-seq to identify RTKs and their ligands enriched in hypermetastatic NB cells as compared to less metastatic parental cells. I identified four RTKs, PDGFRA, PDGFRB, EGFR, and FGFR1 and found that the PDGFRB ligand PDGFBB mediated the migration and invasion of the hypermetastatic cells without markedly affecting the parental cells. These findings suggest that NB cells use PDGF to mediate part of the metastatic process.
590 $a School code: 0779.
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650 4 $a Medicine. $3 641104
650 4 $a Cellular biology. $3 3172791
653 $a Cancer
653 $a Neuroblastoma
653 $a Receptor tyrosine kinases
653 $a Metastatic process
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