東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Spatial Integration of Natural Scene...

Freedland, Julian.

FindBook

Google Book

Amazon

博客來

Spatial Integration of Natural Scenes in the Mammalian Retina.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Spatial Integration of Natural Scenes in the Mammalian Retina./
作者:	Freedland, Julian.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	101 p.
附註:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
標題:	Neurosciences. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30526960
ISBN:	9798379909642

Spatial Integration of Natural Scenes in the Mammalian Retina.
Freedland, Julian.

Spatial Integration of Natural Scenes in the Mammalian Retina. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 101 p.

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--University of Washington, 2023.

The human visual system relies on neural signals that travel along the optic nerve from the eye to the brain. Signals within the optic nerve are generated by individual neurons ("ganglion cells") that reside within the retina and produce neural spikes in response to specific visual inputs. Establishing a causal link between the visual features in a single scene and the subsequent spike response of retinal ganglion cells is an important step in developing a complete understanding of human vision - and can aid the design of prosthetic eyes that restore sight.In this dissertation, we focus our efforts towards how retinal ganglion cells in the mammalian retina encode realistic scenes from the natural world ("natural scenes"). Natural scenes are typically difficult to study in the retina due to their high dimensionality (large number of pixels) and complex statistical structure (how pixels are arranged). In Chapter 2, we gain traction on this problem by simplifying the spatial structure of natural movies and asking, using electrophysiological techniques, whether these simplifications are reflected in the spike responses of retinal ganglion cells. We find that in parasol ganglion cells, natural movies with 16 wedge-shaped pixels elicit similar responses to the original natural movie. Importantly, these simplified stimuli perform consistently across populations of neurons and only require knowledge of the neuron's classical receptive field, enabling relatively accurate predictions of neural responses to natural scenes with minimal inputs.In Chapter 3, we utilize a similar electrophysiological approach to investigate whether retinal ganglion cells can resolve certain spatial disruptions to natural scenes. We find that breaking the spatial structure of images (introducing "spatial discontinuities") uniformly delays spike responses. Our work provides insight into how complex visual inputs are encoded by the mammalian visual system.

ISBN: 9798379909642Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Dimensional reduction

Spatial Integration of Natural Scenes in the Mammalian Retina.
LDR:03128nmm a2200409 4500 001 2401077
005 20241015112516.5
006 m o d
007 cr#unu||||||||
008 251215s2023 ||||||||||||||||| ||eng d
020 $a 9798379909642
035 $a (MiAaPQ)AAI30526960
035 $a AAI30526960
035 $a 2401077
040 $a MiAaPQ $c MiAaPQ
100 1 $a Freedland, Julian. $3 3771139
245 1 0 $a Spatial Integration of Natural Scenes in the Mammalian Retina.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 101 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
500 $a Advisor: Rieke, Fred.
502 $a Thesis (Ph.D.)--University of Washington, 2023.
520 $a The human visual system relies on neural signals that travel along the optic nerve from the eye to the brain. Signals within the optic nerve are generated by individual neurons ("ganglion cells") that reside within the retina and produce neural spikes in response to specific visual inputs. Establishing a causal link between the visual features in a single scene and the subsequent spike response of retinal ganglion cells is an important step in developing a complete understanding of human vision - and can aid the design of prosthetic eyes that restore sight.In this dissertation, we focus our efforts towards how retinal ganglion cells in the mammalian retina encode realistic scenes from the natural world ("natural scenes"). Natural scenes are typically difficult to study in the retina due to their high dimensionality (large number of pixels) and complex statistical structure (how pixels are arranged). In Chapter 2, we gain traction on this problem by simplifying the spatial structure of natural movies and asking, using electrophysiological techniques, whether these simplifications are reflected in the spike responses of retinal ganglion cells. We find that in parasol ganglion cells, natural movies with 16 wedge-shaped pixels elicit similar responses to the original natural movie. Importantly, these simplified stimuli perform consistently across populations of neurons and only require knowledge of the neuron's classical receptive field, enabling relatively accurate predictions of neural responses to natural scenes with minimal inputs.In Chapter 3, we utilize a similar electrophysiological approach to investigate whether retinal ganglion cells can resolve certain spatial disruptions to natural scenes. We find that breaking the spatial structure of images (introducing "spatial discontinuities") uniformly delays spike responses. Our work provides insight into how complex visual inputs are encoded by the mammalian visual system.
590 $a School code: 0250.
650 4 $a Neurosciences. $3 588700
650 4 $a Biophysics. $3 518360
650 4 $a Physiology. $3 518431
650 4 $a Molecular biology. $3 517296
653 $a Dimensional reduction
653 $a Encoding
653 $a Retinal ganglion cells
653 $a Sensory systems
653 $a Neurons
690 $a 0317
690 $a 0786
690 $a 0307
690 $a 0719
710 2 $a University of Washington. $b Molecular Engineering and Sciences. $3 3691018
773 0 $t Dissertations Abstracts International $g 85-01B.
790 $a 0250
791 $a Ph.D.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30526960