東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Unraveling the Role of the Human Gut...

Cowley, Elise S.,

FindBook

Google Book

Amazon

博客來

Unraveling the Role of the Human Gut Microbiome in Three Conditions: Colorectal Cancer, Group B Streptococcus Colonization, and Multiple Sclerosis /

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Unraveling the Role of the Human Gut Microbiome in Three Conditions: Colorectal Cancer, Group B Streptococcus Colonization, and Multiple Sclerosis // Elise S Cowley.
作者:	Cowley, Elise S.,
面頁冊數:	1 electronic resource (420 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
標題:	Microbiology. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30989452
ISBN:	9798381402780

Unraveling the Role of the Human Gut Microbiome in Three Conditions: Colorectal Cancer, Group B Streptococcus Colonization, and Multiple Sclerosis /
Cowley, Elise S.,

Unraveling the Role of the Human Gut Microbiome in Three Conditions: Colorectal Cancer, Group B Streptococcus Colonization, and Multiple Sclerosis /Elise S Cowley. - 1 electronic resource (420 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

The human gut microbiome is widely studied primarily through compositional and descriptive studies. Different human health and disease statuses have been linked to both the gut microbiome composition and function. To understand the role of the human microbiome in human health and disease, in this thesis, I have paired compositional characterizations with functional potential via metabolic reconstruction. I utilized human samples paired with participant metadata to understand the role of the gut microbiome in three different health conditions: colorectal cancer (CRC), multiple sclerosis (MS), and group B Streptococcus (GBS) colonization. I investigated the role of bacterial sulfur cycle potential in the human gut and its impact on colorectal cancer (CRC) by describing the scope of the bacterial sulfur cycle in the human gut and associations of particular microbial sulfidogenic pathways with colorectal cancer using ~17,000 bacterial genomes from a cohort of 667 individuals (chapter 2). We found bacterial sulfur cycle genes are common in the gut and several genes are associated with CRC. Next, I determined the prevalence of group B Streptococcus in the human gut in the general adult population using stool samples, and evaluated dietary and health risk factors for GBS colonization using 754 stool samples from adults in Wisconsin (chapter 3). In this work, we found GBS is present in 18% of stool samples and an increased abundance of GBS is associated with decreased dental hygiene and increased frequency of iron consumption. Finally, I investigated the role of bacteria and bacteriophages in relapsing remitting multiple sclerosis (RRMS) by evaluating the bacterial and phage composition and functional landscape of the gut microbiome in 75 individuals with RRMS compared to controls from a community in Wisconsin (chapter 4). We found the overall bacterial and phage composition of the gut similar between controls and participants with RRMS. We found the Semi-phosphorylative Entner-Doudoroff pathway, was less likely to be present in in the assembled genomes of participants with MS on disease modifying therapy than those who are not on disease modifying therapy and tryptophan biosynthesis was more likely to be present in bacterial genomes of individuals with RRMS not on disease modifying therapy compared to controls. By understanding the composition and functional capacity of the microbiome in different disease states using human samples, we can better understand how to combine therapeutic approaches to change the composition and function of the microbiome (Figure 1).

English

ISBN: 9798381402780Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Colorectal cancer

Unraveling the Role of the Human Gut Microbiome in Three Conditions: Colorectal Cancer, Group B Streptococcus Colonization, and Multiple Sclerosis /
LDR:04244nmm a22004573i 4500 001 2400554
005 20250522084153.5
006 m o d
007 cr|nu||||||||
008 251215s2024 miu||||||m |||||||eng d
020 $a 9798381402780
035 $a (MiAaPQD)AAI30989452
035 $a AAI30989452
040 $a MiAaPQD $b eng $c MiAaPQD $e rda
100 1 $a Cowley, Elise S., $e author. $3 3770606
245 1 0 $a Unraveling the Role of the Human Gut Microbiome in Three Conditions: Colorectal Cancer, Group B Streptococcus Colonization, and Multiple Sclerosis / $c Elise S Cowley.
264 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 1 electronic resource (420 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
500 $a Advisors: Anantharaman, Karthik; Hryckowian, Andrew Committee members: Nett, Jeniel; Safdar, Nasia; Jacques, Laura.
502 $b Ph.D. $c The University of Wisconsin - Madison $d 2024.
520 $a The human gut microbiome is widely studied primarily through compositional and descriptive studies. Different human health and disease statuses have been linked to both the gut microbiome composition and function. To understand the role of the human microbiome in human health and disease, in this thesis, I have paired compositional characterizations with functional potential via metabolic reconstruction. I utilized human samples paired with participant metadata to understand the role of the gut microbiome in three different health conditions: colorectal cancer (CRC), multiple sclerosis (MS), and group B Streptococcus (GBS) colonization. I investigated the role of bacterial sulfur cycle potential in the human gut and its impact on colorectal cancer (CRC) by describing the scope of the bacterial sulfur cycle in the human gut and associations of particular microbial sulfidogenic pathways with colorectal cancer using ~17,000 bacterial genomes from a cohort of 667 individuals (chapter 2). We found bacterial sulfur cycle genes are common in the gut and several genes are associated with CRC. Next, I determined the prevalence of group B Streptococcus in the human gut in the general adult population using stool samples, and evaluated dietary and health risk factors for GBS colonization using 754 stool samples from adults in Wisconsin (chapter 3). In this work, we found GBS is present in 18% of stool samples and an increased abundance of GBS is associated with decreased dental hygiene and increased frequency of iron consumption. Finally, I investigated the role of bacteria and bacteriophages in relapsing remitting multiple sclerosis (RRMS) by evaluating the bacterial and phage composition and functional landscape of the gut microbiome in 75 individuals with RRMS compared to controls from a community in Wisconsin (chapter 4). We found the overall bacterial and phage composition of the gut similar between controls and participants with RRMS. We found the Semi-phosphorylative Entner-Doudoroff pathway, was less likely to be present in in the assembled genomes of participants with MS on disease modifying therapy than those who are not on disease modifying therapy and tryptophan biosynthesis was more likely to be present in bacterial genomes of individuals with RRMS not on disease modifying therapy compared to controls. By understanding the composition and functional capacity of the microbiome in different disease states using human samples, we can better understand how to combine therapeutic approaches to change the composition and function of the microbiome (Figure 1).
546 $a English
590 $a School code: 0262
650 4 $a Microbiology. $3 536250
650 4 $a Oncology. $3 751006
650 4 $a Bioengineering. $3 657580
650 4 $a Genetics. $3 530508
653 $a Colorectal cancer
653 $a Group B Streptococcus
653 $a Human gut microbiome
653 $a Multiple sclerosis
653 $a Biosynthesis
690 $a 0410
690 $a 0202
690 $a 0992
690 $a 0369
710 2 $a The University of Wisconsin - Madison. $b Microbiology ALS. $e degree granting institution. $3 3770607
720 1 $a Anantharaman, Karthik $e degree supervisor.
720 1 $a Hryckowian, Andrew $e degree supervisor.
773 0 $t Dissertations Abstracts International $g 85-07B.
790 $a 0262
791 $a Ph.D.
792 $a 2024
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30989452