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Prognostic Performance of Combined H...

Nwanne, Chamberlain U.,

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Prognostic Performance of Combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in Recipients of Allogeneic Hematopoietic Cell Transplants for Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Prognostic Performance of Combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in Recipients of Allogeneic Hematopoietic Cell Transplants for Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes // Chamberlain U Nwanne.
Author:	Nwanne, Chamberlain U.,
Description:	1 electronic resource (85 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 85-07, Section: B.
Contained By:	Dissertations Abstracts International85-07B.
Subject:	Bioinformatics. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30819371
ISBN:	9798381382150

Prognostic Performance of Combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in Recipients of Allogeneic Hematopoietic Cell Transplants for Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes /
Nwanne, Chamberlain U.,

Prognostic Performance of Combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in Recipients of Allogeneic Hematopoietic Cell Transplants for Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes /Chamberlain U Nwanne. - 1 electronic resource (85 pages)

Source: Dissertations Abstracts International, Volume: 85-07, Section: B.

Prognostic performance of combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in recipients of allogeneic hematopoietic cell transplants for patients with acute myeloid leukemia and myelodysplastic syndromes.Medical prognostication models based on both clinical and non-clinical characteristics are used to estimate the risk of outcomes in individuals undergoing hematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome. It is imperative that clinical decision makers have accurate tools for pre-transplant risk-benefit assessment that would allow for optimal stratification of patients to determine suitability of hematopoietic cell transplants (HCT), maximize the benefits of HCT to the patients and aid transplant centers optimize their resources. Using educational level, occupation status and income level as factors of socioeconomic status (SES) index, this study combines SES with hematopoietic cell transplantation comorbidity index (HCT-CI) and age before transplant to develop a new prognostic tool for overall survival and non-relapse mortality outcomes for patients with acute myeloid leukemia and myelodysplastic syndromes at Memorial Sloan Kettering Cancer Center (MSKCC). The predictive capabilities of the new HCT-CI/Age/SES for this single center cohort were compared to the HCT-CI and HCT-CI/Age. At 95% Confidence Interval, estimates of adjusted c-statistic for overall survival were 0.673 and 0.676 for HCT-CI and HCT-CI/Age, respectively, while it was 0.652 for HCT-CI/Age/SES index. The predictive capability of the latter suggests that the new tool can be a valuable prognostic assessment for overall survival outcome. Delineating the relative importance of SES and each of the individual factors, the SES index did not significantly predict either overall survival or non-relapse mortality at 2 years post HCT in this patient cohort. Advances in research, novel therapies, treatment expertise and optimal follow-up protocols at MSKCC may have contributed to ameliorate the impact of low SES; suggesting that with access to the same expert care, lower SES individuals can achieve similar treatment outcomes as those at higher SES levels.

English

ISBN: 9798381382150Subjects--Topical Terms:

553671
Bioinformatics.
Subjects--Index Terms:

Cell transplant

Prognostic Performance of Combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in Recipients of Allogeneic Hematopoietic Cell Transplants for Patients with Acute Myeloid Leukemia and Myelodysplastic Syndromes /
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520 $a Prognostic performance of combined Hematopoietic Cell Transplantation - Comorbidity Index, Age and Socioeconomic Status in recipients of allogeneic hematopoietic cell transplants for patients with acute myeloid leukemia and myelodysplastic syndromes.Medical prognostication models based on both clinical and non-clinical characteristics are used to estimate the risk of outcomes in individuals undergoing hematopoietic cell transplant for acute myeloid leukemia and myelodysplastic syndrome. It is imperative that clinical decision makers have accurate tools for pre-transplant risk-benefit assessment that would allow for optimal stratification of patients to determine suitability of hematopoietic cell transplants (HCT), maximize the benefits of HCT to the patients and aid transplant centers optimize their resources. Using educational level, occupation status and income level as factors of socioeconomic status (SES) index, this study combines SES with hematopoietic cell transplantation comorbidity index (HCT-CI) and age before transplant to develop a new prognostic tool for overall survival and non-relapse mortality outcomes for patients with acute myeloid leukemia and myelodysplastic syndromes at Memorial Sloan Kettering Cancer Center (MSKCC). The predictive capabilities of the new HCT-CI/Age/SES for this single center cohort were compared to the HCT-CI and HCT-CI/Age. At 95% Confidence Interval, estimates of adjusted c-statistic for overall survival were 0.673 and 0.676 for HCT-CI and HCT-CI/Age, respectively, while it was 0.652 for HCT-CI/Age/SES index. The predictive capability of the latter suggests that the new tool can be a valuable prognostic assessment for overall survival outcome. Delineating the relative importance of SES and each of the individual factors, the SES index did not significantly predict either overall survival or non-relapse mortality at 2 years post HCT in this patient cohort. Advances in research, novel therapies, treatment expertise and optimal follow-up protocols at MSKCC may have contributed to ameliorate the impact of low SES; suggesting that with access to the same expert care, lower SES individuals can achieve similar treatment outcomes as those at higher SES levels.
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