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Mechanical Stimulation Microfluidic ...

Moore, Ira Nigel.

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Mechanical Stimulation Microfluidic Devices for Brain Organoid Mechanobiology.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mechanical Stimulation Microfluidic Devices for Brain Organoid Mechanobiology./
作者:	Moore, Ira Nigel.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	49 p.
附註:	Source: Masters Abstracts International, Volume: 85-06.
Contained By:	Masters Abstracts International85-06.
標題:	Bioengineering. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30573663
ISBN:	9798381108880

Mechanical Stimulation Microfluidic Devices for Brain Organoid Mechanobiology.
Moore, Ira Nigel.

Mechanical Stimulation Microfluidic Devices for Brain Organoid Mechanobiology. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 49 p.

Source: Masters Abstracts International, Volume: 85-06.

Thesis (M.S.)--North Carolina Agricultural and Technical State University, 2023.

Brain organoids, clusters of nerve cells derived from human pluripotent stem cells, provide a valuable in vitro model to simulate human brain development and neurological disease behavior. The use of this novel organic material could reduce the time and the cost of research in addition to the need for animal testing to increase the understanding of the human neurological system. However, current systems for brain organoid cell culture need to be improved for more reliable production. Despite the potential of brain organoid technology, obstacles remain that prevent further success. Due to instructive signals and biomechanical forces not being present during the growth of cerebral organoids, they develop only some of the earliest stages of human embryonic brain development and do not efficiently mimic the later stages of neurogenesis. Hence there is a need for more biologically accurate culture material from an organoid culture that can address the subject limitations of current technology. What's more, a mechanically active model, which incorporates compression, interstitial pressure, and flow will improve the development of organoids in terms of proliferation, morphology, and growth. Fabricated PDMS microfluidic devices are ideal for performing this specific biological experimentation for their adaptability and inexpensive nature. We propose that PDMS-based diffusion generator devices with compression chambers can be an option for efficient culture of brain organoids. The proposed device will closely mimic the biological/chemical composition of the natural microenvironment and sustain the mechanical forces required for development. Our goal is to create abio-mimetic model capable of mechanical stimulation and test organoids growth with them, which should result in a reliable culture platform for the analysis of neurological diseases, treatments and brain development.

ISBN: 9798381108880Subjects--Topical Terms:

657580
Bioengineering.
Subjects--Index Terms:

Brain organoids

Mechanical Stimulation Microfluidic Devices for Brain Organoid Mechanobiology.
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300 $a 49 p.
500 $a Source: Masters Abstracts International, Volume: 85-06.
500 $a Advisor: Yun, Yeoheung.
502 $a Thesis (M.S.)--North Carolina Agricultural and Technical State University, 2023.
520 $a Brain organoids, clusters of nerve cells derived from human pluripotent stem cells, provide a valuable in vitro model to simulate human brain development and neurological disease behavior. The use of this novel organic material could reduce the time and the cost of research in addition to the need for animal testing to increase the understanding of the human neurological system. However, current systems for brain organoid cell culture need to be improved for more reliable production. Despite the potential of brain organoid technology, obstacles remain that prevent further success. Due to instructive signals and biomechanical forces not being present during the growth of cerebral organoids, they develop only some of the earliest stages of human embryonic brain development and do not efficiently mimic the later stages of neurogenesis. Hence there is a need for more biologically accurate culture material from an organoid culture that can address the subject limitations of current technology. What's more, a mechanically active model, which incorporates compression, interstitial pressure, and flow will improve the development of organoids in terms of proliferation, morphology, and growth. Fabricated PDMS microfluidic devices are ideal for performing this specific biological experimentation for their adaptability and inexpensive nature. We propose that PDMS-based diffusion generator devices with compression chambers can be an option for efficient culture of brain organoids. The proposed device will closely mimic the biological/chemical composition of the natural microenvironment and sustain the mechanical forces required for development. Our goal is to create abio-mimetic model capable of mechanical stimulation and test organoids growth with them, which should result in a reliable culture platform for the analysis of neurological diseases, treatments and brain development.
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