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The Role of Alternative Polyadenylat...

Washington State University., Department of Animal Sciences.

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The Role of Alternative Polyadenylation in Genome Function and Health Implications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of Alternative Polyadenylation in Genome Function and Health Implications./
Author:	Carrion, Shane A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2024,
Description:	145 p.
Notes:	Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
Contained By:	Dissertations Abstracts International85-12B.
Subject:	Biology. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31145705
ISBN:	9798383137208

The Role of Alternative Polyadenylation in Genome Function and Health Implications.
Carrion, Shane A.

The Role of Alternative Polyadenylation in Genome Function and Health Implications. - Ann Arbor : ProQuest Dissertations & Theses, 2024 - 145 p.

Source: Dissertations Abstracts International, Volume: 85-12, Section: B.

Thesis (Ph.D.)--Washington State University, 2024.

Transcript diversity is a key biological advantage in complex lifeforms, allowing an organism to manufacture a wide range of transcript and gene products from a limited selection of genes. Of the three main mechanisms of transcript diversity (alternative splicing, alternative transcription start, and alternative polyadenylation), alternative polyadenylation or APA, has the highest impact on proteins alongside alternative start sites. APA is prevalent in eukaryotes, evolutionarily conserved, and more than 50% of human genes contain 3 or more APA sites. Imprinted genes, which display monoallelic expression on a parent-of-origin specific basis due to epigenetic modifications, remain a unique and still underexplored gene set. This offered the opportunity to explore what unique traits imprinted genes shared compared to a set in the functionally similar sex differentiation set and investigate their use of APA sites and involvement in pathways from a cattle gene set whose APA patterns had been assigned. Despite the increase in study of APA over the past two decades, categorical and pathway APA patterning (gene and pathway specific) remained relatively unexplored. We demonstrated a method of categorizing APA site use using biological pathways, such as gene ontology, on pathways with a specific focus, in this instance hormones. Hormones have strong regulatory effects throughout the body, meaning misregulation of these pathways can quickly lead to disease states. Hormone clusters formed using APA profiles (assigned by APA patterning), combined with other factors, displayed coherent function, with each cluster displaying a unique APA profile. APA profiling also allows for identification of distinct profile differences between related groups and links with pathways outside of the explored class.

ISBN: 9798383137208Subjects--Topical Terms:

522710
Biology.
Subjects--Index Terms:

Alternative polyadenylation

The Role of Alternative Polyadenylation in Genome Function and Health Implications.
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245 1 0 $a The Role of Alternative Polyadenylation in Genome Function and Health Implications.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2024
300 $a 145 p.
500 $a Source: Dissertations Abstracts International, Volume: 85-12, Section: B.
500 $a Includes supplementary digital materials.
500 $a Advisor: Jiang, Zhihua.
502 $a Thesis (Ph.D.)--Washington State University, 2024.
520 $a Transcript diversity is a key biological advantage in complex lifeforms, allowing an organism to manufacture a wide range of transcript and gene products from a limited selection of genes. Of the three main mechanisms of transcript diversity (alternative splicing, alternative transcription start, and alternative polyadenylation), alternative polyadenylation or APA, has the highest impact on proteins alongside alternative start sites. APA is prevalent in eukaryotes, evolutionarily conserved, and more than 50% of human genes contain 3 or more APA sites. Imprinted genes, which display monoallelic expression on a parent-of-origin specific basis due to epigenetic modifications, remain a unique and still underexplored gene set. This offered the opportunity to explore what unique traits imprinted genes shared compared to a set in the functionally similar sex differentiation set and investigate their use of APA sites and involvement in pathways from a cattle gene set whose APA patterns had been assigned. Despite the increase in study of APA over the past two decades, categorical and pathway APA patterning (gene and pathway specific) remained relatively unexplored. We demonstrated a method of categorizing APA site use using biological pathways, such as gene ontology, on pathways with a specific focus, in this instance hormones. Hormones have strong regulatory effects throughout the body, meaning misregulation of these pathways can quickly lead to disease states. Hormone clusters formed using APA profiles (assigned by APA patterning), combined with other factors, displayed coherent function, with each cluster displaying a unique APA profile. APA profiling also allows for identification of distinct profile differences between related groups and links with pathways outside of the explored class.
590 $a School code: 0251.
650 4 $a Biology. $3 522710
650 4 $a Genetics. $3 530508
650 4 $a Evolution & development. $3 3172418
650 4 $a Endocrinology. $3 610914
653 $a Alternative polyadenylation
653 $a Comparative genomics
653 $a RNA variants
653 $a Transcript diversity
653 $a Hormones
690 $a 0306
690 $a 0369
690 $a 0412
690 $a 0409
710 2 $a Washington State University. $b Department of Animal Sciences. $3 3768318
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791 $a Ph.D.
792 $a 2024
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=31145705