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Development of a Novel Three-dimensi...

Rafieedolatabadi, Negar.

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Development of a Novel Three-dimensional Parallel-plate Biochemical Sensor for Electrochemical Impedance Spectroscopy (EIS).

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of a Novel Three-dimensional Parallel-plate Biochemical Sensor for Electrochemical Impedance Spectroscopy (EIS)./
作者:	Rafieedolatabadi, Negar.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	62 p.
附註:	Source: Masters Abstracts International, Volume: 84-11.
Contained By:	Masters Abstracts International84-11.
標題:	Mechanical engineering. -
電子資源:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30423935
ISBN:	9798379510824

Development of a Novel Three-dimensional Parallel-plate Biochemical Sensor for Electrochemical Impedance Spectroscopy (EIS).
Rafieedolatabadi, Negar.

Development of a Novel Three-dimensional Parallel-plate Biochemical Sensor for Electrochemical Impedance Spectroscopy (EIS). - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 62 p.

Source: Masters Abstracts International, Volume: 84-11.

Thesis (M.S.)--Southern Illinois University at Edwardsville, 2023.

This item must not be sold to any third party vendors.

Miniaturized electrochemical impedance-based sensors have emerged as a powerful tool for detection of chemical and biological agents at extremely low concentrations. These sensors operate by measuring changes in electrical impedance of analytes when they are subjected to an AC signal, and have found applications in fields ranging from medical diagnosis to environmental monitoring and food safety analysis. Most electrochemical impedance-based sensors in the literature feature a two-dimensional (planar) geometry, with two interdigitated electrodes. Interdigitated electrodes have been successfully used in the past for detection of different biochemical agents. The work presented in this thesis offer a novel geometry for electrodes, a three-dimensional parallel-plate based electrode configuration, where one of the two electrodes is stacked on the top of another one. This geometry is particularly designed to mimic the porous structure of fresh produce and is intended to be used to simulate the interaction of foodborne pathogens with produce in the sensor, such that we can investigate the behavior of the microorganisms, especially their penetration and growth under the surface. In order to assess the efficacy of the sensors in detecting bacteria, a phthalate chemical compound called DEHP (Di(2-ethylhexyl) phthalate) was selected as an initial step, as it is simpler to characterize and control compared to using the bacteria themselves. The sensor consists of a digitated electrode patterned on a substrate, and a planar and porous electrode suspended above the fixed electrode. This architecture offers several advantages over planar sensors. For example, the suspended electrode increases the surface area available for analyte binding, while the 3D geometry provides a platform to simulate the surface structure of fruits and vegetables. The sensor is fabricated using PolyMUMPs, a standard and high-precision microfabrication process that enables the production of complex microelectromechanical systems (MEMS) with a high degree of accuracy and reproducibility. The experimental results show that the three-dimensional sensor has distinct Nyquist responses for concentrations of 0 ppm, 0.02 ppm, 0.2 ppm, 2 ppm, 10 ppm and 20 ppm of DEHP. The Nyquist plot also provides information about the electrochemical behavior of the sensor, including the formation of a double-layer capacitance and the transport of charge at high frequencies, as well as diffusion at low frequencies. Interestingly, the results show that, in contrast to interdigitated geometry, the electrostatic field within the solution is noticeable for 3D parallel-plate sensors. The parallel-plate capacitance due to the electrostatic filed and high dielectric of the solution significantly affects the Nyquist response, which has important advantage for the proposed sensor design for biological detection. The electrochemical behavior of sensor-solution sample is analyzed using and equivalent circuit model that simulates the electrochemical phenomena in the solution. The circuit simulations verify the notable effects of parallel-plate capacitance and electrostatic forces on the sensor's response and also electrochemical effects such as diffusion at low frequencies and formation of double-layer capacitance at higher frequencies.

ISBN: 9798379510824Subjects--Topical Terms:

649730
Mechanical engineering.
Subjects--Index Terms:

Biosensor

Development of a Novel Three-dimensional Parallel-plate Biochemical Sensor for Electrochemical Impedance Spectroscopy (EIS).
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260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 62 p.
500 $a Source: Masters Abstracts International, Volume: 84-11.
500 $a Advisor: Shavezipur, Mohammad.
502 $a Thesis (M.S.)--Southern Illinois University at Edwardsville, 2023.
506 $a This item must not be sold to any third party vendors.
520 $a Miniaturized electrochemical impedance-based sensors have emerged as a powerful tool for detection of chemical and biological agents at extremely low concentrations. These sensors operate by measuring changes in electrical impedance of analytes when they are subjected to an AC signal, and have found applications in fields ranging from medical diagnosis to environmental monitoring and food safety analysis. Most electrochemical impedance-based sensors in the literature feature a two-dimensional (planar) geometry, with two interdigitated electrodes. Interdigitated electrodes have been successfully used in the past for detection of different biochemical agents. The work presented in this thesis offer a novel geometry for electrodes, a three-dimensional parallel-plate based electrode configuration, where one of the two electrodes is stacked on the top of another one. This geometry is particularly designed to mimic the porous structure of fresh produce and is intended to be used to simulate the interaction of foodborne pathogens with produce in the sensor, such that we can investigate the behavior of the microorganisms, especially their penetration and growth under the surface. In order to assess the efficacy of the sensors in detecting bacteria, a phthalate chemical compound called DEHP (Di(2-ethylhexyl) phthalate) was selected as an initial step, as it is simpler to characterize and control compared to using the bacteria themselves. The sensor consists of a digitated electrode patterned on a substrate, and a planar and porous electrode suspended above the fixed electrode. This architecture offers several advantages over planar sensors. For example, the suspended electrode increases the surface area available for analyte binding, while the 3D geometry provides a platform to simulate the surface structure of fruits and vegetables. The sensor is fabricated using PolyMUMPs, a standard and high-precision microfabrication process that enables the production of complex microelectromechanical systems (MEMS) with a high degree of accuracy and reproducibility. The experimental results show that the three-dimensional sensor has distinct Nyquist responses for concentrations of 0 ppm, 0.02 ppm, 0.2 ppm, 2 ppm, 10 ppm and 20 ppm of DEHP. The Nyquist plot also provides information about the electrochemical behavior of the sensor, including the formation of a double-layer capacitance and the transport of charge at high frequencies, as well as diffusion at low frequencies. Interestingly, the results show that, in contrast to interdigitated geometry, the electrostatic field within the solution is noticeable for 3D parallel-plate sensors. The parallel-plate capacitance due to the electrostatic filed and high dielectric of the solution significantly affects the Nyquist response, which has important advantage for the proposed sensor design for biological detection. The electrochemical behavior of sensor-solution sample is analyzed using and equivalent circuit model that simulates the electrochemical phenomena in the solution. The circuit simulations verify the notable effects of parallel-plate capacitance and electrostatic forces on the sensor's response and also electrochemical effects such as diffusion at low frequencies and formation of double-layer capacitance at higher frequencies.
590 $a School code: 0509.
650 4 $a Mechanical engineering. $3 649730
650 4 $a Biomedical engineering. $3 535387
650 4 $a Analytical chemistry. $3 3168300
653 $a Biosensor
653 $a EIS
653 $a MEMS
653 $a Electrochemical impedance spectroscopy
653 $a Microelectromechanical systems
690 $a 0548
690 $a 0486
690 $a 0541
710 2 $a Southern Illinois University at Edwardsville. $b Mechanical Engineering. $3 3555237
773 0 $t Masters Abstracts International $g 84-11.
790 $a 0509
791 $a M.S.
792 $a 2023
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30423935