東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Linked to FindBook

Google Book

Amazon

博客來

Alternate programmed cell death signaling in antiviral host defense

Record Type:	Electronic resources : Monograph/item
Title/Author:	Alternate programmed cell death signaling in antiviral host defense/ edited by Edward S. Mocarski, Pratyusha Mandal.
other author:	Mocarski, Edward S.
Published:	Cham :Springer International Publishing : : 2023.,
Description:	v, 174 p. :ill., digital ;24 cm.
[NT 15003449]:	Programmed Necrosis in Host Defense -- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis -- Pyroptosis in Antiviral Immunity -- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus -- Subversion of Programed Cell Death by Poxviruses -- Cell Killing by Reovirus: Mechanisms and Consequences -- Outcomes of RIP kinase signaling during neuroinvasive viral infection.
Contained By:	Springer Nature eBook
Subject:	Virus diseases - Immunological aspects. -
Online resource:	https://doi.org/10.1007/978-3-031-45278-9
ISBN:	9783031452789

Alternate programmed cell death signaling in antiviral host defense
Alternate programmed cell death signaling in antiviral host defense[electronic resource] /edited by Edward S. Mocarski, Pratyusha Mandal. - Cham :Springer International Publishing :2023. - v, 174 p. :ill., digital ;24 cm. - Current topics in microbiology and immunology,v. 4422196-9965 ;. - Current topics in microbiology and immunology ;v. 442..

Programmed Necrosis in Host Defense -- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis -- Pyroptosis in Antiviral Immunity -- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus -- Subversion of Programed Cell Death by Poxviruses -- Cell Killing by Reovirus: Mechanisms and Consequences -- Outcomes of RIP kinase signaling during neuroinvasive viral infection.

This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3) This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.

ISBN: 9783031452789

Standard No.: 10.1007/978-3-031-45278-9doiSubjects--Topical Terms:

895219
Virus diseases
--Immunological aspects.

LC Class. No.: QR201.V55 / A58 2023

Dewey Class. No.: 571.96

Alternate programmed cell death signaling in antiviral host defense
LDR:03564nmm a2200337 a 4500 001 2389809
003 DE-He213
005 20231216112241.0
006 m d
007 cr nn 008maaau
008 250916s2023 sz s 0 eng d
020 $a 9783031452789 $q (electronic bk.)
020 $a 9783031452772 $q (paper)
024 7 $a 10.1007/978-3-031-45278-9 $2 doi
035 $a 978-3-031-45278-9
040 $a GP $c GP
041 0 $a eng
050 4 $a QR201.V55 $b A58 2023
072 7 $a MJCM $2 bicssc
072 7 $a MED044000 $2 bisacsh
072 7 $a MJCM $2 thema
082 0 4 $a 571.96 $2 23
090 $a QR201.V55 $b A466 2023
245 0 0 $a Alternate programmed cell death signaling in antiviral host defense $h [electronic resource] / $c edited by Edward S. Mocarski, Pratyusha Mandal.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2023.
300 $a v, 174 p. : $b ill., digital ; $c 24 cm.
490 1 $a Current topics in microbiology and immunology, $x 2196-9965 ; $v v. 442
505 0 $a Programmed Necrosis in Host Defense -- ZBP1/DAI-dependent Cell Death Pathways in Influenza A Virus Immunity and Pathogenesis -- Pyroptosis in Antiviral Immunity -- Manipulation of Host Cell Death Pathways by Herpes Simplex Virus -- Subversion of Programed Cell Death by Poxviruses -- Cell Killing by Reovirus: Mechanisms and Consequences -- Outcomes of RIP kinase signaling during neuroinvasive viral infection.
520 $a This volume provides a comprehensive review of programmed cell death pathways and their fundamental role in antiviral host defense. The book deep-dives into the molecular functions and regulation of necroptosis and discusses how viruses induce and manipulate this potent innate cellular sensing system. Initially, understanding of necroptosis emerged from studies on tumor necrosis factor (TNF) signaling that showed the key role of receptor interacting protein kinase 1 (RIPK1) in the activation of receptor interacting protein kinase 3 (RIPK3) which then phosphorylates mixed lineage kinase domain like pseudokinase (MLKL) to execute cells via plasma membrane leakage of cytosolic contents. Since its discovery, multiple facets of the RIPK3-dependent necroptotic machinery have evolved where the requirements for execution of death varies depending on the stimulus. Virus-induced necroptosis was discovered over 10 years ago in studies on murine cytomegalovirus (MCMV) where a virus-encoded inhibitor was shown to prevent the recruitment of RIPK3 (RIP3) This transformative evidence identified a novel pathway acting independent of TNF, interferon or RIPK1 that can stop virus from infecting its natural mouse host by killing off infected cells to halt replication. Over the past decade influenza A virus (IAV), herpes simplex virus (HSV) and poxvirus vaccinia (VACV) have all been shown to trigger the pathway. Herpesviruses and poxviruses also encode inhibitors of caspase-8 whose elaboration unleashes the necroptosis pathway. IAV and other RNA viruses do not encode programmed cell death inhibitors. RIPK3 is also known to induce apoptosis by recruiting RIPK1 as shown nearly a decade ago and this dual apoptosis/necroptosis induction occurs naturally during influenza A virus infection. RIPK3 is also able to induce an inflammatory response independently of programmed cell death that can predominate to drive inflammatory disease outcomes. This volume is a must-read for researchers and advanced students in immunology and virology.
650 0 $a Virus diseases $x Immunological aspects. $3 895219
650 0 $a Cell death. $3 665792
650 1 4 $a Immunology. $3 611031
650 2 4 $a Medical Microbiology. $3 890951
650 2 4 $a Virology. $3 642304
700 1 $a Mocarski, Edward S. $3 3755721
700 1 $a Mandal, Pratyusha. $3 3755722
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Current topics in microbiology and immunology ; $v v. 442. $3 3755723
856 4 0 $u https://doi.org/10.1007/978-3-031-45278-9
950 $a Biomedical and Life Sciences (SpringerNature-11642)