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Section 1: Molecular Biology, Biochemistry, and Functioning of the GABAB Receptor -- GABAB Receptor: Molecular Organization, Function, and Alternative Drug Development by Targeting Protein-Protein Interactions -- GABAB Receptor Functioning: Focus on Allosteric Modulation -- Section 2: Pharmacology of Baclofen -- Historical Overview on Baclofen, the Only GABAB Receptor Agonist Approved and Available for Clinical Use -- Baclofen for the Treatment of Spasticity and Dystonia in Cerebral Palsy -- Baclofen for the Treatment of Cough -- Baclofen for the Treatment of Alcohol Use Disorder -- Baclofen Safety, Toxicity, Withdrawal, and Overdose -- Section 3: Chemistry and Pharmacology of Positive Allosteric Modulators -- Recent Advances on Chemistry of GABAB Receptor Allosteric Modulators -- GABAB Receptor Positive Allosteric Modulators: Novel Approaches for Drug Design and Discovery -- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Neuropsychiatric Disorders -- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Substance Use Disorder and Food Addiction -- Recent Advances on GABAB Receptor Positive Allosteric Modulators as Potential Pharmacotherapies for Alcohol Use Disorder -- Section 4: Miscellanea -- γ-Hydroxybutiric Acid: A GABAB/GHB Receptor Agonist with a Unique Neuropharmacological and Therapeutic Profile -- Naturally Occurring GABAB Receptor Ligands -- Norman G. Bowery: A Founding Father of the GABAB Receptor Research Field - Reflections on His Contribution. |