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A guide to sample size for animal-based studies

Record Type:	Electronic resources : Monograph/item
Title/Author:	A guide to sample size for animal-based studies/ Penny S. Reynolds.
Author:	Reynolds, Penny S.
Published:	Hoboken, NJ :Wiley-Blackwell, : 2024.,
Description:	1 online resource (280 p.) :ill. (some col.)
Subject:	Animal experimentation - Methods. -
Online resource:	https://onlinelibrary.wiley.com/doi/book/10.1002/9781119800002
ISBN:	9781119800002

A guide to sample size for animal-based studies
Reynolds, Penny S.

A guide to sample size for animal-based studies[electronic resource] /Penny S. Reynolds. - 1st ed. - Hoboken, NJ :Wiley-Blackwell,2024. - 1 online resource (280 p.) :ill. (some col.)

Includes bibliographical references and index.

"How large a sample size do I need for my study"? Although one of the most commonly-asked questions in statistics, the importance of proper sample size estimation seems to be overlooked by many preclinical researchers. Over the past two decades, numerous reviews of the published literature indicate many studies are too small to answer the research question and results are too unreliable to be trusted. Few published studies present adequate justification of their chosen sample sizes, or even report the total number of animals used. On the other hand, it is not unusual for protocols (usually those involving mouse models) to request preposterous numbers of animals, sometimes in the tens or even hundreds of thousands, "because this is an exploratory study, so it is unknown how many animals we will require."--

ISBN: 9781119800002Subjects--Topical Terms:

3720671
Animal experimentation
--Methods.

LC Class. No.: R853.A53 / R49 2024

Dewey Class. No.: 616.02/7

National Library of Medicine Call No.: W 20.55.A5

A guide to sample size for animal-based studies
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020 $z 9781119799979 $q (paperback)
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245 1 2 $a A guide to sample size for animal-based studies $h [electronic resource] / $c Penny S. Reynolds.
250 $a 1st ed.
260 $a Hoboken, NJ : $b Wiley-Blackwell, $c 2024.
300 $a 1 online resource (280 p.) : $b ill. (some col.)
504 $a Includes bibliographical references and index.
520 $a "How large a sample size do I need for my study"? Although one of the most commonly-asked questions in statistics, the importance of proper sample size estimation seems to be overlooked by many preclinical researchers. Over the past two decades, numerous reviews of the published literature indicate many studies are too small to answer the research question and results are too unreliable to be trusted. Few published studies present adequate justification of their chosen sample sizes, or even report the total number of animals used. On the other hand, it is not unusual for protocols (usually those involving mouse models) to request preposterous numbers of animals, sometimes in the tens or even hundreds of thousands, "because this is an exploratory study, so it is unknown how many animals we will require."-- $c Provided by publisher
588 $a Description based on print version record.
650 0 $a Animal experimentation $x Methods. $3 3720671
650 0 $a Research $x Methodology. $3 529338
650 1 2 $a Animal Experimentation. $3 886433
650 2 2 $a Sample Size. $3 1535344
856 4 0 $u https://onlinelibrary.wiley.com/doi/book/10.1002/9781119800002